Methods and Applications of Cohort Studies
June 21-25, 2021
1:30 p.m. – 5:00 p.m.
Course Number: 340.706.11
This summer this course will be taught online via Zoom, on the dates and times listed above. Registered students will attend their classes virtually via Zoom, in real time with faculty and other students.
General methods will be taught and applied to cohort studies of chronic and infectious disease, including HIV, COVID-19, cardiovascular disease and cancer. Topics to be discussed include: definition, design and basic characteristics of interval and clinical cohort studies; conceptual underpinnings of survival analysis; use of discrete-time and continuous-time survival analysis; methods for the analysis of survival data including modelling and testing of relative hazards (Cox regression), relative times (parametric regression), and relative incidence (Poisson and negative binomial regression); methods to nest case-control and case-cohort designs in cohort studies; and a discussion of key challenges in the conduct and analysis of modern cohort studies.
Student Evaluation: 3 labs completed in class and handed in for grading
Upon successfully completing this course, students will be able to: 1. Describe the principles for the design and conduct of cohort studies; 2. Estimate and compare incidence rates, and times-to-event via relative hazards and relative times; 3. Apply analytic methods to data from large, long-term and multicenter cohort studies coordinated by the instructors’ research team; 4. Appreciate the role of cohort studies for the characterization of natural history of diseases; for evaluation of interventions and for guiding public policy
Prerequisite: Intermediate-level courses in both epidemiology and biostatistics and some familiarity with data analysis software packages.
Grading Options: Letter Grade or Pass/Fail
Special Comments: Students who have successfully completed 340.728: Methods and Applications of Cohort Studies should not enroll in this course
Course Materials: Provided in class and through CoursePlus