Arsenic and other metals: association with cytokine dysregulation and risk of Hepatitis E infection in pregnant women
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- Baltimore Healthy Schools: Impact of Indoor Air Quality on Health and Performance
- Exposure Assessment for Epidemiologic Studies
- Exposures from Oil Spills
- Kirsten Koehler's Research Team
- Occupational Hazard Mapping
- Particulate Exposures in Asthmatic Kids (PEAK)
- Personal Exposure Assessment
- Publications
- Spatiotemporal Exposure Assessment
- Within Baltimore Variability in Pollution
- Kohr Laboratory of Cardiovascular Redox Signaling
- One Health Laboratory at Johns Hopkins University
- Animal Visitation Chlorhexidine Trial
- Baltimore Healthy Schools: Impact of Indoor Air Quality on Health and Performance
- Collaborators
- Dr. Meghan Davis Receives Canine Health Foundation Grant to Study the Health of Dogs
- Group on the Integration of the Relationship between Animals, Public Health and Ethics
- News and Publications
- One Health Research Team
- The COVET Study
- The CoWelf Study
- The Minority Pet-Owner Health Project
- Zoonotic Spillover Projects
- COVID-19 Human-Animal Interactions Survey (CHAIS)
- Research Program Gurumurthy Ramachandran, PhD
- Climate Change, Pesticide Use, and Exposures
- Computed Tomography and Low-cost Sensor Networks to Reconstruct Spatial Pollutant Distributions
- Decision-making for Risk Management Using Small Data Sets, Mathematical Models, and Heuristics
- Infrastructure for Delivering and Characterizing Airborne Exposures in Exposure Chambers
- Mathematical Modeling of Chemical Exposures
- Meet Ram's Team...
- Modeling of Infectious Diseases
- The Exposome Collaborative @ Johns Hopkins University
- The Johns Hopkins Environmental Health Microbiology and Immunology Laboratory
- Dr. Kirsten Koehler Faculty Research
- Geyh-Bouwer Trainee Practice Award
- Grand Rounds
- Mobile Air Pollution Measurement Laboratory
- Research Areas
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- Antimicrobial Resistance and Infectious Disease
- Biosecurity and Emerging Threats
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- Epigenetic Regulation in Environmental Diseases
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- Geomorphology, Geochemistry, and Hydrology
- Global Environmental Change
- Novel Exposure Assessment
- Risk Sciences and Public Policy
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- Toxicology, Physiology, & Cell Biology
- Water, Sanitation, Hygiene, and Health
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- The INnovations to Generate Estimates of children's Soil/dust inTake (INGEST) Study
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Hepatitis E virus (HEV) is the leading global cause of acute viral hepatitis, particularly in Bangladesh and other parts of South Asia where seasonal floods contaminate drinking water supplies, causing large annual hepatitis E (HE) epidemics.
Despite a case-fatality rate of only 3.0% in the general population, pregnant women infected with HEV genotype 1 in South Asia suffer disproportionately elevated mortality (10-40%) for reasons that are unclear. Much of Bangladesh is also affected by high exposures to naturally occurring arsenic – a well-recognized toxicant known to cause inflammation and liver damage – via contaminated groundwater supplies. My research proposes an exploratory analysis of the role of arsenic and other metal exposures as predictors of cytokine dysregulation and, potentially, HE seroconversion in pregnancy using existing biospecimens and data from a longitudinal cohort study of pregnant women in Bangladesh (JiVitA Maternal and Child Health and Nutrition Research Project)