Publications
- Kabir, R., Sinha, P., Mishra, S., Ebenebe, O., Taube, N., Oening, C., Keceli, G., Chen, R., Paolocci, N., Rule, A., Kohr, M.J. Inorganic arsenic induces sex-dependent pathological hypertrophy in the heart. Am J Physiol Heart Circ Physiol. 320(4): H1321-H1336; 2021
- Casin, K., Kohr, M.J. An emerging perspective on sex differences: Intersecting S-nitrosothiol and aldehyde signaling in the heart. Redox Biology. 31: 101441; 2020.
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Roman, B., Kaur, P., Ashok, D., Kohr, M.J., Biswas, R., O’Rourke, B., Murphy, E., Steenbergen, C., Das, S. Nuclear-mitochondrial communication involving miR-181c plays a pivotal role in cardiac dysfunction during obesity. J Mol Cell Cardiol. 144:87-96; 2020.
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Fillmore, N., Casin, K.M., Sinha, P., Sun, J., Ma, H., Boylston, J., Noguchi, A., Liu, C., Wang, N., Zhou, G., Murphy, E., Kohr, M.J. A knock-in mutation at cysteine 144 of TRIM72 is cardioprotective and reduces myocardial TRIM72 secretion. J Mol Cell Cardiol. 136: 95-101; 2019.
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Banavath, H.N., Roman, B., Mackowski, N., Biswas, D., Azfal, J., Nomura, Y., Solhjoo, S., O’Rourke, B., Kohr, M.J., Murphy, E., Steenbergen, C., Das, S. miR-181c activates mitochondrial calcium uptake by regulating MICU1 in the heart. J Am Heart Assoc. 8(24): e012919; 2019.
- Bian, Z., Wang, Q., Zhou, X., Tan, T., Park, K.H., Adesanya, T., Sermersheim, M., Yi., F., Wang, X., Wu, J., Gummper, K., Jiang, Q., Lin, P., Li, H., Guan, F., Zhou, J., Kohr, M.J., Zeng, C., Zhu, H., Ma, J. Sustained elevation of MG53 in the bloodstream increases tissue regenerative capacity without compromising metabolic function
- Veenema, R., Casin, K.M., Sinha, P., Kabir, R., Mackowski, N., Taube, N., Bedja, D., Chen, R., Rule, A., Kohr, M.J. Inorganic arsenic exposure induces sex disparate effects and exacerbates ischemia-reperfusion injury in the female heart. Am J Physiol Heart Circ Physiol. 316(5): H1053-H1064; 2019.
- Tian, R., Colucci, W.S., Arany, Z., Bachschmid, M.M., Ballinger, S., Boudina, S., Bruce, J.E., Busija, D.W., Dikalov, S., Dorn, G.W., Galis, Z.S., Gottleib, R.A., Kelly, D.P., Kitsis, R.N., Kohr, M.J., Levy, D., Lewandowski, D., McClung, J.M., Mochly-Rosen, D., O’Brien, K.D., O’Rourke, B., Park, J.Y., Ping, P., Sack, M.N., Sheu, S-S., Shi, Y., Shiva, S., Wallace, D.C., Weiss, R.G., Vernon, H.J., Wong, R., Schwartz-Longacre, L. Unlocking the secrets of mitochondria in the cardiovascular system: Path to a cure in heart failure, A report from the 2018 National Heart, Lung and Blood workshop. Circulation. 140:1205-1216; 2019.
- Casin, K., Fallica, J., Mackowski, N., Veenema, R., Chan, A., St. Paul, A., Zhu, G., Bedja, D., Biswal, S., Kohr, M.J. S-nitrosoglutathione reductase is essential for protecting the female heart from ischemia-reperfusion injury. Circ Res. 123(11): 1232-1243; 2018.
- Qin, S., Casin, K.M., Mackowski, N., Murphy, E., Steenbergen, C., Kohr, M.J. Adenosine A1receptor activation increases myocardial protein S-nitrosothiols and elicits protection in male and female hearts. PLoS One. 12(5): e0177315; 2017.
- Das, S., Kohr, M.J., Dunkerly-Eyring, B., Bedja, D., Kent, O., Leung, A., Henao-Mejia, J., Flavell, R., Steenbergen, C. Role of miR-181 family in the heart: a tale of two intracellular compartments. J Am Heart Assoc. 6(3): e004694; 2017.
- Zhang, B., Novitskaya, T., Wheeler, D.G., Xu, Z., Chepurko, E., Huttinger, R., He, H., Varadharaj, S., Zweier, J.L., Song, Y., Xu, M., Harrell, F.E., Su, Y.R., Absi, R.S., Kohr, M.J., Ziolo, M.T., Roden, D.M., Shaffer, C.M., Galindo, C.L., Wells, Q.S., Gumina, R.J. Down-regulated KCNJ11 gene expression in ischemic cardiomyopathy contributes to an inability to modulate the nitro-oxidative stress of ischemia-reperfusion injury. Circ Heart Fail. 10(2): e003523; 2017.
- Murray, C.I., Chung, H.S., Papanicolaou, K., Foster, D.B., Kohr, M.J.# Post-translational modifications in the cardiovascular proteome (2016). (Book Chapter, Manual of Cardiovascular Protoemics. Edited by Agnetti, G. et al., Spring International Publishing).
- Shao, Q., Fallica, J., Casin, K.M., Murphy, E., Steenbergen, C. Kohr, M.J.# Characterization of the sex-dependent myocardial S-nitrosothiol proteome. Am J Physiol Heart Circ Physiol. 310:H505-515; 2016. #Corresponding author
- Kohr, M.J. Mitsugumin-53: Potential biomarker and therapeutic for myocardial ischemic injury? J Mol Cell Cardiol. 81:46-48; 2015.
- Sun, J., Nguyen, T., Aponte, A.M., Menazza, S., Kohr, M.J., Roth, D.M., Patel, H.M., Murphy, E., Steenbergen, C. Ischaemic preconditioning preferentially increases protein S-nitrosylation in subsarcolemmal mitochondria. Cardiovasc Res. 106(2):227-236; 2015.
- Kovacs, M., Kiss, A., Gonczi, M. Miskolczi, G., Seprenyi, G., Kaszaki, J., Kohr, M.J., Murphy, E., Vegh, A. Effect of sodium nitrite on ischemia and reperfusion-induced arrhythmias in anaesthetized dogs: is protein S-nitrosylation involved? PLoS One. 10:e0122243; 2015.
- Kohr, M.J.#, Murphy, E., Steenbergen, C. GAPDH acts as a mitochondrial trans-S-nitrosylase in the myocardium. PLOS One. 9:e111448; 2014.#Corresponding author
- Kohr, M.J.#, Evangelista, A., Ferlito, M., Steenbergen, C., Murphy, E. S-nitrosylation of TRIM72 at cysteine 144 is critical for protection against oxidation-induced protein degradation and cell death. J Mol Cell Cardiol. 69:67-74; 2014. #Corresponding author, Comment in: X’avia Chan, C.Y., Wang, D., Cadeiras, M., Deng, M.C., Ping, P. S-nitrosylation of TRIM72 mends the broken heart: A molecular modifier-mediated cardioprotection. J Mol Cell Cardiol. 72:292-295; 2014.
- Tong, G., Aponte, A., Kohr, M.J., Steenbergen, C., Murphy, E., Sun, J. Postconditioning leads to an increase in protein S-nitrosylation. Am J Physiol Heart Circ Physiol. 306: H825-H832; 2014.
- Murphy, E., Kohr, M., Menazza, S., Nguyen, T., Evangelista, A., Sun, J., Steenbergen, C. Signaling by S-nitrosylation in the heart. J Mol Cell Cardiol. 73:18-25; 2014.
- Sun, J., Nguyen, T., Kohr, M.J., Murphy, E. Cardioprotective role of caveolae in ischemia-reperfusion injury. Transl Med. 3:114; 2013.
- Evangelista, A., Kohr, M.J., Murphy, E. S-nitrosylation: Specificity, occupancy, and interaction with other post-translational modifications. Antioxid Redox Signal. 19:1209-1219; 2013.
- Kohr, M.J., Aponte, A., Sun, J., Gucek, M., Steenbergen, C., Murphy, E., Measurement of S-nitrosylation occupancy in the myocardium with cysteine-reactive tandem mass tags. Circ Res. 111:1308-12; 2012. Circulation Research Editor’s Pick, Comment in: Murray, C.I., Van Eyk, J.E. A twist on quantification: measuring the site occupancy of S-nitrosylation. Circ Res. 111:1253-5; 2012.
- Kohr, M.J., Roof, S., Zweier, J., Ziolo, M.T. Modulation of myocardial contraction by peroxynitrite. Front Physio. 3:468; 2012.
- Sun, J., Aponte, A.M., Kohr, M.J., Tong, G., Steenbergen, C., Murphy, E. Essential role of nitric oxide in acute ischemic preconditioning: S-nitros(yl)ation vs. sGC/cGMP/PKG signaling? Free Radic Biol Med. 54:105-112; 2012.
- Wang, H., Bonilla, I., Huang, X., He, Q., Kohr, M.J., Carnes, C., Ziolo, M. Prolonged action potential and afterdepoloarizations are not due to changes in potassium currents in NOS3 knockout ventricular myocytes. J Signal Transduct. 2012:645721; 2012.
- Kohr, M.J., Sun, J., Aponte, A., Wang, G., Gucek, M., Murphy, E., Steenbergen, C. Simultaneous measurement of protein oxidation and S-nitrosylation during preconditioning and ischemia/reperfusion injury with resin-assisted capture. Circ Res. 108:418-426; 2011. Cited by Faculty of 1000 as a Recommended Article
- Kohr, M.J., Aponte, A., Sun, J., Wang, G., Murphy, E., Gucek, M., Steenbergen, C. Characterization of potential S-nitrosylation sites in the myocardium. Am J Physiol Heart Circ Physiol. 300:H1327-1335; 2011.
- Murphy, E., Kohr, M., Sun, J., Nguyen, T., Steenbergen, C. S-nitrosylation: A radical way to protect the heart. J Mol Cell Cardiol. 52: 568-577; 2011.
- Sun, J., Kohr, M.J., Nguyen, T., Aponte, A., Connelly, P.S., Esfahani, S.G., Gucek, M., Daniels, M.P., Steenbergen, C., Murphy, E. Disruption of caveolae blocks preconditioning-mediated S-nitrosylation of mitochondrial proteins. Antioxid Redox Signal. 16:45-56; 2011.
- Nguyen, T., Stevens, M., Kohr, M., Steenbergen, C., Sack, M., Murphy, E. Cysteine 203 of Cyclophilin D is critical for cyclophilin D activation of the mitochondrial permeability transition pore. J Biol Chem. 286: 40184-92; 2011. Cited by Faculty of 1000 as a Recommended Article
- Murphy, E., Lagranha, C., Deschamps, A., Kohr, M., Nguyen, T., Wong, R., Sun, J., Steenbergen, C. Mechanism of cardioprotection: What can we learn from females? Pediatr Cardiol. 32: 354-359; 2011.
- Wang, H., Viatchenko-Karpinski, S., Sun, J., Gyorke, I., Benkusky, N., Kohr, M.J., Valdivia, H., Murphy, E., Gyorke, S., Ziolo, M. Regulation of myocyte contraction via neuronal nitric oxide synthase: role of ryanodine receptor S-nitrosylation. J Phys. 588:2905-2917; 2010.
- Kohr, M.J., Traynham, C.J., Roof, S.R., Davis, J.P., Ziolo, M.T. cAMP-independent activation of protein kinase A by the peroxynitrite generator SIN-1 elicits positive inotropic effects in cardiomyocytes. J Mol Cell Cardiol. 45:645-648; 2010.
- Kohr, M.J., Kaludercic, N., Tocchetti, C.G., Gao, W.D., Kass, D.A., Janssen, P.M, Paolocci, N., Ziolo, M.T. Nitroxyl enhances cardiomyocyte Ca2+ transients by exclusively targeting sarcoplasmic reticulum Ca2+-cycling. Front in Biosci. E2:614-626; 2009.
- Wang, H., Kohr, M.J., Traynham, C.J. Ziolo, M.T. Phosphodiesterase Type 5 Restricts NOS3/Soluble Guanylate cyclase signaling to the L-type Ca2+ current. J Mol Cell Cardiol. 47: 304-314; 2009.
- Kohr, M.J., Davis, J.P., Ziolo, M.T. Peroxynitrite increases protein phosphatase activity and promotes the interaction of phospholamban with protein phosphatase 2a in the myocardium. Nitric Oxide. 20:217-221; 2009.
- Ziolo, M.T., Kohr, M.J., Wang, H. Nitric oxide signaling and the regulation of myocardial function. J Mol Cell Cardiol. 45:625-632; 2008.
- Wang, H., Kohr, M.J., Wheeler, D.G., Traynham, C.J., Janssen, P.M., Ziolo, M.T. Neuronal nitric oxide synthase signaling within cardiac myocytes targets phospholamban. Am J Physiol Cell Physiol. 294: C1566-1575; 2008.
- Kohr, M.J., Wang, H., Wheeler, D.G., Velayutham, M., Zweier, J.L., Ziolo, M.T. Biphasic effect of SIN-1 is reliant upon cardiomyocyte contractile state. Free Radic Biol and Med. 45:73-80; 2008.
- Wang, H., Kohr, M.J., Wheeler, D.G., Ziolo, M.T. Endothelial nitric oxide synthase decreases b-adrenergic responsiveness via inhibition of the L-type Ca2+ current. Am J Physiol Heart Circ Physiol. 294: H1473-1480; 2008.
- Kohr, M.J., Wang, H., Wheeler, D.G., Velayutham, M., Zweier, J.L., Ziolo, M.T. Targeting of phospholamban by peroxynitrite decreases b-adrenergic stimulation in cardiomyocytes. Cardiovasc Res. 77:353-361; 2008.
- Rosen, G.M., Burks, S.R., Kohr, M.J., Kao, J.P. Synthesis and biological testing of aminoxyls designed for long-term retention by living cells. Org Biomol Chem. 3: 645-648; 2005.