Skip to main content

A cross-divisional department spanning

Kohr Laboratory of Cardiovascular Redox Signaling


  1. Kabir, R., Sinha, P., Mishra, S., Ebenebe, O., Taube, N., Oening, C., Keceli, G., Chen, R., Paolocci, N., Rule, A., Kohr, M.J. Inorganic arsenic induces sex-dependent pathological hypertrophy in the heart. Am J Physiol Heart Circ Physiol. 320(4): H1321-H1336; 2021
  2. Casin, K., Kohr, M.J. An emerging perspective on sex differences: Intersecting S-nitrosothiol and aldehyde signaling in the heart. Redox Biology. 31: 101441; 2020.
  3. Roman, B., Kaur, P., Ashok, D., Kohr, M.J., Biswas, R., O’Rourke, B., Murphy, E., Steenbergen, C., Das, S. Nuclear-mitochondrial communication involving miR-181c plays a pivotal role in cardiac dysfunction during obesity. J Mol Cell Cardiol. 144:87-96; 2020.

  4. Fillmore, N., Casin, K.M., Sinha, P., Sun, J., Ma, H., Boylston, J., Noguchi, A., Liu, C., Wang, N., Zhou, G., Murphy, E., Kohr, M.J. A knock-in mutation at cysteine 144 of TRIM72 is cardioprotective and reduces myocardial TRIM72 secretion. J Mol Cell Cardiol. 136: 95-101; 2019.

  5. Banavath, H.N., Roman, B., Mackowski, N., Biswas, D., Azfal, J., Nomura, Y., Solhjoo, S., O’Rourke, B., Kohr, M.J., Murphy, E., Steenbergen, C., Das, S. miR-181c activates mitochondrial calcium uptake by regulating MICU1 in the heart. J Am Heart Assoc. 8(24): e012919; 2019.

  6. Bian, Z., Wang, Q., Zhou, X., Tan, T., Park, K.H., Adesanya, T., Sermersheim, M., Yi., F., Wang, X., Wu, J., Gummper, K., Jiang, Q., Lin, P., Li, H., Guan, F., Zhou, J., Kohr, M.J., Zeng, C., Zhu, H., Ma, J. Sustained elevation of MG53 in the bloodstream increases tissue regenerative capacity without compromising metabolic function
  7. Veenema, R., Casin, K.M., Sinha, P., Kabir, R., Mackowski, N., Taube, N., Bedja, D., Chen, R., Rule, A., Kohr, M.J. Inorganic arsenic exposure induces sex disparate effects and exacerbates ischemia-reperfusion injury in the female heart. Am J Physiol Heart Circ Physiol. 316(5): H1053-H1064; 2019. 
  8. Tian, R., Colucci, W.S., Arany, Z., Bachschmid, M.M., Ballinger, S., Boudina, S., Bruce, J.E., Busija, D.W., Dikalov, S., Dorn, G.W., Galis, Z.S., Gottleib, R.A., Kelly, D.P., Kitsis, R.N., Kohr, M.J., Levy, D., Lewandowski, D., McClung, J.M., Mochly-Rosen, D., O’Brien, K.D., O’Rourke, B., Park, J.Y., Ping, P., Sack, M.N., Sheu, S-S., Shi, Y., Shiva, S., Wallace, D.C., Weiss, R.G., Vernon, H.J., Wong, R., Schwartz-Longacre, L. Unlocking the secrets of mitochondria in the cardiovascular system: Path to a cure in heart failure, A report from the 2018 National Heart, Lung and Blood workshop. Circulation. 140:1205-1216; 2019.
  9. Casin, K., Fallica, J., Mackowski, N., Veenema, R., Chan, A., St. Paul, A., Zhu, G., Bedja, D., Biswal, S., Kohr, M.J. S-nitrosoglutathione reductase is essential for protecting the female heart from ischemia-reperfusion injury. Circ Res. 123(11): 1232-1243; 2018.
  10. Qin, S., Casin, K.M., Mackowski, N., Murphy, E., Steenbergen, C., Kohr, M.J. Adenosine A1receptor activation increases myocardial protein S-nitrosothiols and elicits protection in male and female hearts. PLoS One. 12(5): e0177315; 2017.
  11. Das, S., Kohr, M.J., Dunkerly-Eyring, B., Bedja, D., Kent, O., Leung, A., Henao-Mejia, J., Flavell, R., Steenbergen, C. Role of miR-181 family in the heart: a tale of two intracellular compartments. J Am Heart Assoc. 6(3): e004694; 2017.
  12. Zhang, B., Novitskaya, T., Wheeler, D.G., Xu, Z., Chepurko, E., Huttinger, R., He, H., Varadharaj, S., Zweier, J.L., Song, Y., Xu, M., Harrell, F.E., Su, Y.R., Absi, R.S., Kohr, M.J., Ziolo, M.T., Roden, D.M., Shaffer, C.M., Galindo, C.L., Wells, Q.S., Gumina, R.J. Down-regulated KCNJ11 gene expression in ischemic cardiomyopathy contributes to an inability to modulate the nitro-oxidative stress of ischemia-reperfusion injury. Circ Heart Fail. 10(2): e003523; 2017.
  13. Murray, C.I., Chung, H.S., Papanicolaou, K., Foster, D.B., Kohr, M.J.# Post-translational modifications in the cardiovascular proteome (2016). (Book Chapter, Manual of Cardiovascular Protoemics. Edited by Agnetti, G. et al., Spring International Publishing).
  14. Shao, Q., Fallica, J., Casin, K.M., Murphy, E., Steenbergen, C. Kohr, M.J.# Characterization of the sex-dependent myocardial S-nitrosothiol proteome. Am J Physiol Heart Circ Physiol. 310:H505-515; 2016. #Corresponding author
  15. Kohr, M.J. Mitsugumin-53: Potential biomarker and therapeutic for myocardial ischemic injury? J Mol Cell Cardiol. 81:46-48; 2015.
  16. Sun, J., Nguyen, T., Aponte, A.M., Menazza, S., Kohr, M.J., Roth, D.M., Patel, H.M., Murphy, E., Steenbergen, C. Ischaemic preconditioning preferentially increases protein S-nitrosylation in subsarcolemmal mitochondria. Cardiovasc Res. 106(2):227-236; 2015.
  17. Kovacs, M., Kiss, A., Gonczi, M. Miskolczi, G., Seprenyi, G., Kaszaki, J., Kohr, M.J., Murphy, E., Vegh, A. Effect of sodium nitrite on ischemia and reperfusion-induced arrhythmias in anaesthetized dogs: is protein S-nitrosylation involved? PLoS One. 10:e0122243; 2015.
  18. Kohr, M.J.#, Murphy, E., Steenbergen, C. GAPDH acts as a mitochondrial trans-S-nitrosylase in the myocardiumPLOS One. 9:e111448; 2014.#Corresponding author
  19. Kohr, M.J.#, Evangelista, A., Ferlito, M., Steenbergen, C., Murphy, E. S-nitrosylation of TRIM72 at cysteine 144 is critical for protection against oxidation-induced protein degradation and cell death. J Mol Cell Cardiol. 69:67-74; 2014. #Corresponding author, Comment in: X’avia Chan, C.Y., Wang, D., Cadeiras, M., Deng, M.C., Ping, P. S-nitrosylation of TRIM72 mends the broken heart: A molecular modifier-mediated cardioprotection. J Mol Cell Cardiol. 72:292-295; 2014.
  20. Tong, G., Aponte, A., Kohr, M.J., Steenbergen, C., Murphy, E., Sun, J. Postconditioning leads to an increase in protein S-nitrosylationAm J Physiol Heart Circ Physiol. 306: H825-H832; 2014.
  21. Murphy, E., Kohr, M., Menazza, S., Nguyen, T., Evangelista, A., Sun, J., Steenbergen, C. Signaling by S-nitrosylation in the heartJ Mol Cell Cardiol. 73:18-25; 2014.
  22. Sun, J., Nguyen, T., Kohr, M.J., Murphy, E. Cardioprotective role of caveolae in ischemia-reperfusion injuryTransl Med. 3:114; 2013.
  23. Evangelista, A., Kohr, M.J., Murphy, E. S-nitrosylation: Specificity, occupancy, and interaction with other post-translational modificationsAntioxid Redox Signal. 19:1209-1219; 2013.
  24. Kohr, M.J., Aponte, A., Sun, J., Gucek, M., Steenbergen, C., Murphy, E., Measurement of S-nitrosylation occupancy in the myocardium with cysteine-reactive tandem mass tagsCirc Res. 111:1308-12; 2012. Circulation Research Editor’s Pick, Comment in: Murray, C.I., Van Eyk, J.E. A twist on quantification: measuring the site occupancy of S-nitrosylationCirc Res. 111:1253-5; 2012.
  25. Kohr, M.J., Roof, S., Zweier, J., Ziolo, M.T. Modulation of myocardial contraction by peroxynitriteFront Physio. 3:468; 2012.
  26. Sun, J., Aponte, A.M., Kohr, M.J., Tong, G., Steenbergen, C., Murphy, E. Essential role of nitric oxide in acute ischemic preconditioning: S-nitros(yl)ation vs. sGC/cGMP/PKG signaling? Free Radic Biol Med. 54:105-112; 2012.
  27. Wang, H., Bonilla, I., Huang, X., He, Q., Kohr, M.J., Carnes, C., Ziolo, M. Prolonged action potential and afterdepoloarizations are not due to changes in potassium currents in NOS3 knockout ventricular myocytesJ Signal Transduct. 2012:645721; 2012.
  28. Kohr, M.J., Sun, J., Aponte, A., Wang, G., Gucek, M., Murphy, E., Steenbergen, C. Simultaneous measurement of protein oxidation and S-nitrosylation during preconditioning and ischemia/reperfusion injury with resin-assisted captureCirc Res. 108:418-426; 2011. Cited by Faculty of 1000 as a Recommended Article
  29. Kohr, M.J., Aponte, A., Sun, J., Wang, G., Murphy, E., Gucek, M., Steenbergen, C. Characterization of potential S-nitrosylation sites in the myocardium. Am J Physiol Heart Circ Physiol. 300:H1327-1335; 2011.
  30. Murphy, E., Kohr, M., Sun, J., Nguyen, T., Steenbergen, C. S-nitrosylation: A radical way to protect the heartJ Mol Cell Cardiol. 52: 568-577; 2011.
  31. Sun, J., Kohr, M.J., Nguyen, T., Aponte, A., Connelly, P.S., Esfahani, S.G., Gucek, M., Daniels, M.P., Steenbergen, C., Murphy, E. Disruption of caveolae blocks preconditioning-mediated S-nitrosylation of mitochondrial proteinsAntioxid Redox Signal. 16:45-56; 2011.
  32. Nguyen, T., Stevens, M., Kohr, M., Steenbergen, C., Sack, M., Murphy, E. Cysteine 203 of Cyclophilin D is critical for cyclophilin D activation of the mitochondrial permeability transition poreJ Biol Chem. 286: 40184-92; 2011. Cited by Faculty of 1000 as a Recommended Article
  33. Murphy, E., Lagranha, C., Deschamps, A., Kohr, M., Nguyen, T., Wong, R., Sun, J., Steenbergen, C. Mechanism of cardioprotection: What can we learn from females? Pediatr Cardiol. 32: 354-359; 2011.
  34. Wang, H., Viatchenko-Karpinski, S., Sun, J., Gyorke, I., Benkusky, N., Kohr, M.J., Valdivia, H., Murphy, E., Gyorke, S., Ziolo, M. Regulation of myocyte contraction via neuronal nitric oxide synthase: role of ryanodine receptor S-nitrosylationJ Phys. 588:2905-2917; 2010.
  35. Kohr, M.J., Traynham, C.J., Roof, S.R., Davis, J.P., Ziolo, M.T. cAMP-independent activation of protein kinase A by the peroxynitrite generator SIN-1 elicits positive inotropic effects in cardiomyocytesJ Mol Cell Cardiol. 45:645-648; 2010.
  36. Kohr, M.J., Kaludercic, N., Tocchetti, C.G., Gao, W.D., Kass, D.A., Janssen, P.M, Paolocci, N., Ziolo, M.T. Nitroxyl enhances cardiomyocyte Ca2+ transients by exclusively targeting sarcoplasmic reticulum Ca2+-cyclingFront in Biosci. E2:614-626; 2009.
  37. Wang, H., Kohr, M.J., Traynham, C.J. Ziolo, M.T. Phosphodiesterase Type 5 Restricts NOS3/Soluble Guanylate cyclase signaling to the L-type Ca2+ currentJ Mol Cell Cardiol. 47: 304-314; 2009.
  38. Kohr, M.J., Davis, J.P., Ziolo, M.T. Peroxynitrite increases protein phosphatase activity and promotes the interaction of phospholamban with protein phosphatase 2a in the myocardiumNitric Oxide. 20:217-221; 2009.
  39. Ziolo, M.T., Kohr, M.J., Wang, H. Nitric oxide signaling and the regulation of myocardial functionJ Mol Cell Cardiol. 45:625-632; 2008.
  40. Wang, H., Kohr, M.J., Wheeler, D.G., Traynham, C.J., Janssen, P.M., Ziolo, M.T. Neuronal nitric oxide synthase signaling within cardiac myocytes targets phospholambanAm J Physiol Cell Physiol. 294: C1566-1575; 2008.
  41. Kohr, M.J., Wang, H., Wheeler, D.G., Velayutham, M., Zweier, J.L., Ziolo, M.T. Biphasic effect of SIN-1 is reliant upon cardiomyocyte contractile stateFree Radic Biol and Med. 45:73-80; 2008.
  42. Wang, H., Kohr, M.J., Wheeler, D.G., Ziolo, M.T. Endothelial nitric oxide synthase decreases b-adrenergic responsiveness via inhibition of the L-type Ca2+ currentAm J Physiol Heart Circ Physiol. 294: H1473-1480; 2008.
  43. Kohr, M.J., Wang, H., Wheeler, D.G., Velayutham, M., Zweier, J.L., Ziolo, M.T. Targeting of phospholamban by peroxynitrite decreases b-adrenergic stimulation in cardiomyocytesCardiovasc Res. 77:353-361; 2008.
  44. Rosen, G.M., Burks, S.R., Kohr, M.J., Kao, J.P. Synthesis and biological testing of aminoxyls designed for long-term retention by living cellsOrg Biomol Chem. 3: 645-648; 2005.