A cross-divisional department spanning

Kohr Laboratory of Cardiovascular Redox Signaling

Publications

  1. Kabir, R., Sinha, P., Mishra, S., Ebenebe, O., Taube, N., Oening, C., Keceli, G., Chen, R., Paolocci, N., Rule, A., Kohr, M.J. Inorganic arsenic induces sex-dependent pathological hypertrophy in the heart.(link is external) Am J Physiol Heart Circ Physiol. 320(4): H1321-H1336; 2021
  2. Casin, K., Kohr, M.J. An emerging perspective on sex differences: Intersecting S-nitrosothiol and aldehyde signaling in the heart(link is external). Redox Biology. 31: 101441; 2020.

  3. Roman, B., Kaur, P., Ashok, D., Kohr, M.J., Biswas, R., O’Rourke, B., Murphy, E., Steenbergen, C., Das, S. Nuclear-mitochondrial communication involving miR-181c plays a pivotal role in cardiac dysfunction during obesity(link is external). J Mol Cell Cardiol. 144:87-96; 2020.

  4. Fillmore, N., Casin, K.M., Sinha, P., Sun, J., Ma, H., Boylston, J., Noguchi, A., Liu, C., Wang, N., Zhou, G., Murphy, E., Kohr, M.J. A knock-in mutation at cysteine 144 of TRIM72 is cardioprotective and reduces myocardial TRIM72 secretion(link is external). J Mol Cell Cardiol. 136: 95-101; 2019.

  5. Banavath, H.N., Roman, B., Mackowski, N., Biswas, D., Azfal, J., Nomura, Y., Solhjoo, S., O’Rourke, B., Kohr, M.J., Murphy, E., Steenbergen, C., Das, S. miR-181c activates mitochondrial calcium uptake by regulating MICU1 in the heart(link is external). J Am Heart Assoc. 8(24): e012919; 2019.

  6. Bian, Z., Wang, Q., Zhou, X., Tan, T., Park, K.H., Adesanya, T., Sermersheim, M., Yi., F., Wang, X., Wu, J., Gummper, K., Jiang, Q., Lin, P., Li, H., Guan, F., Zhou, J., Kohr, M.J., Zeng, C., Zhu, H., Ma, J. Sustained elevation of MG53 in the bloodstream increases tissue regenerative capacity without compromising metabolic function(link is external)
  7. Veenema, R., Casin, K.M., Sinha, P., Kabir, R., Mackowski, N., Taube, N., Bedja, D., Chen, R., Rule, A., Kohr, M.J. Inorganic arsenic exposure induces sex disparate effects and exacerbates ischemia-reperfusion injury in the female heart(link is external). Am J Physiol Heart Circ Physiol. 316(5): H1053-H1064; 2019. 
  8. Tian, R., Colucci, W.S., Arany, Z., Bachschmid, M.M., Ballinger, S., Boudina, S., Bruce, J.E., Busija, D.W., Dikalov, S., Dorn, G.W., Galis, Z.S., Gottleib, R.A., Kelly, D.P., Kitsis, R.N., Kohr, M.J., Levy, D., Lewandowski, D., McClung, J.M., Mochly-Rosen, D., O’Brien, K.D., O’Rourke, B., Park, J.Y., Ping, P., Sack, M.N., Sheu, S-S., Shi, Y., Shiva, S., Wallace, D.C., Weiss, R.G., Vernon, H.J., Wong, R., Schwartz-Longacre, L. Unlocking the secrets of mitochondria in the cardiovascular system: Path to a cure in heart failure, A report from the 2018 National Heart, Lung and Blood workshop.(link is external) Circulation. 140:1205-1216; 2019.
  9. Casin, K., Fallica, J., Mackowski, N., Veenema, R., Chan, A., St. Paul, A., Zhu, G., Bedja, D., Biswal, S., Kohr, M.J. S-nitrosoglutathione reductase is essential for protecting the female heart from ischemia-reperfusion injury(link is external). Circ Res. 123(11): 1232-1243; 2018.
  10. Qin, S., Casin, K.M., Mackowski, N., Murphy, E., Steenbergen, C., Kohr, M.J. Adenosine A1receptor activation increases myocardial protein S-nitrosothiols and elicits protection in male and female hearts.(link is external) PLoS One. 12(5): e0177315; 2017.
  11. Das, S., Kohr, M.J., Dunkerly-Eyring, B., Bedja, D., Kent, O., Leung, A., Henao-Mejia, J., Flavell, R., Steenbergen, C. Role of miR-181 family in the heart: a tale of two intracellular compartments.(link is external) J Am Heart Assoc. 6(3): e004694; 2017.
  12. Zhang, B., Novitskaya, T., Wheeler, D.G., Xu, Z., Chepurko, E., Huttinger, R., He, H., Varadharaj, S., Zweier, J.L., Song, Y., Xu, M., Harrell, F.E., Su, Y.R., Absi, R.S., Kohr, M.J., Ziolo, M.T., Roden, D.M., Shaffer, C.M., Galindo, C.L., Wells, Q.S., Gumina, R.J. Down-regulated KCNJ11 gene expression in ischemic cardiomyopathy contributes to an inability to modulate the nitro-oxidative stress of ischemia-reperfusion injury.(link is external) Circ Heart Fail. 10(2): e003523; 2017.
  13. Murray, C.I., Chung, H.S., Papanicolaou, K., Foster, D.B., Kohr, M.J.# Post-translational modifications in the cardiovascular proteome (2016). (Book Chapter, Manual of Cardiovascular Protoemics. Edited by Agnetti, G. et al., Spring International Publishing).
  14. Shao, Q., Fallica, J., Casin, K.M., Murphy, E., Steenbergen, C. Kohr, M.J.# Characterization of the sex-dependent myocardial S-nitrosothiol proteome.(link is external) Am J Physiol Heart Circ Physiol. 310:H505-515; 2016. #Corresponding author
  15. Kohr, M.J. Mitsugumin-53: Potential biomarker and therapeutic for myocardial ischemic injury?(link is external) J Mol Cell Cardiol. 81:46-48; 2015.
  16. Sun, J., Nguyen, T., Aponte, A.M., Menazza, S., Kohr, M.J., Roth, D.M., Patel, H.M., Murphy, E., Steenbergen, C. Ischaemic preconditioning preferentially increases protein S-nitrosylation in subsarcolemmal mitochondria.(link is external) Cardiovasc Res. 106(2):227-236; 2015.
  17. Kovacs, M., Kiss, A., Gonczi, M. Miskolczi, G., Seprenyi, G., Kaszaki, J., Kohr, M.J., Murphy, E., Vegh, A. Effect of sodium nitrite on ischemia and reperfusion-induced arrhythmias in anaesthetized dogs: is protein S-nitrosylation involved?(link is external) PLoS One. 10:e0122243; 2015.
  18. Kohr, M.J.#, Murphy, E., Steenbergen, C. GAPDH acts as a mitochondrial trans-S-nitrosylase in the myocardium(link is external). PLOS One. 9:e111448; 2014.#Corresponding author
  19. Kohr, M.J.#, Evangelista, A., Ferlito, M., Steenbergen, C., Murphy, E. S-nitrosylation of TRIM72 at cysteine 144 is critical for protection against oxidation-induced protein degradation and cell death(link is external). J Mol Cell Cardiol. 69:67-74; 2014. #Corresponding author, Comment in: X’avia Chan, C.Y., Wang, D., Cadeiras, M., Deng, M.C., Ping, P. S-nitrosylation of TRIM72 mends the broken heart: A molecular modifier-mediated cardioprotection(link is external). J Mol Cell Cardiol. 72:292-295; 2014.
  20. Tong, G., Aponte, A., Kohr, M.J., Steenbergen, C., Murphy, E., Sun, J. Postconditioning leads to an increase in protein S-nitrosylation(link is external). Am J Physiol Heart Circ Physiol. 306: H825-H832; 2014.
  21. Murphy, E., Kohr, M., Menazza, S., Nguyen, T., Evangelista, A., Sun, J., Steenbergen, C. Signaling by S-nitrosylation in the heart(link is external). J Mol Cell Cardiol. 73:18-25; 2014.
  22. Sun, J., Nguyen, T., Kohr, M.J., Murphy, E. Cardioprotective role of caveolae in ischemia-reperfusion injury(link is external). Transl Med. 3:114; 2013.
  23. Evangelista, A., Kohr, M.J., Murphy, E. S-nitrosylation: Specificity, occupancy, and interaction with other post-translational modifications(link is external). Antioxid Redox Signal. 19:1209-1219; 2013.
  24. Kohr, M.J., Aponte, A., Sun, J., Gucek, M., Steenbergen, C., Murphy, E., Measurement of S-nitrosylation occupancy in the myocardium with cysteine-reactive tandem mass tags(link is external). Circ Res. 111:1308-12; 2012. Circulation Research Editor’s Pick, Comment in: Murray, C.I., Van Eyk, J.E. A twist on quantification: measuring the site occupancy of S-nitrosylation(link is external). Circ Res. 111:1253-5; 2012.
  25. Kohr, M.J., Roof, S., Zweier, J., Ziolo, M.T. Modulation of myocardial contraction by peroxynitrite(link is external). Front Physio. 3:468; 2012.
  26. Sun, J., Aponte, A.M., Kohr, M.J., Tong, G., Steenbergen, C., Murphy, E. Essential role of nitric oxide in acute ischemic preconditioning: S-nitros(yl)ation vs. sGC/cGMP/PKG signaling?(link is external) Free Radic Biol Med. 54:105-112; 2012.
  27. Wang, H., Bonilla, I., Huang, X., He, Q., Kohr, M.J., Carnes, C., Ziolo, M. Prolonged action potential and afterdepoloarizations are not due to changes in potassium currents in NOS3 knockout ventricular myocytes(link is external). J Signal Transduct. 2012:645721; 2012.
  28. Kohr, M.J., Sun, J., Aponte, A., Wang, G., Gucek, M., Murphy, E., Steenbergen, C. Simultaneous measurement of protein oxidation and S-nitrosylation during preconditioning and ischemia/reperfusion injury with resin-assisted capture(link is external). Circ Res. 108:418-426; 2011. Cited by Faculty of 1000 as a Recommended Article
  29. Kohr, M.J., Aponte, A., Sun, J., Wang, G., Murphy, E., Gucek, M., Steenbergen, C. Characterization of potential S-nitrosylation sites in the myocardium(link is external). Am J Physiol Heart Circ Physiol. 300:H1327-1335; 2011.
  30. Murphy, E., Kohr, M., Sun, J., Nguyen, T., Steenbergen, C. S-nitrosylation: A radical way to protect the heart(link is external). J Mol Cell Cardiol. 52: 568-577; 2011.
  31. Sun, J., Kohr, M.J., Nguyen, T., Aponte, A., Connelly, P.S., Esfahani, S.G., Gucek, M., Daniels, M.P., Steenbergen, C., Murphy, E. Disruption of caveolae blocks preconditioning-mediated S-nitrosylation of mitochondrial proteins(link is external). Antioxid Redox Signal. 16:45-56; 2011.
  32. Nguyen, T., Stevens, M., Kohr, M., Steenbergen, C., Sack, M., Murphy, E. Cysteine 203 of Cyclophilin D is critical for cyclophilin D activation of the mitochondrial permeability transition pore(link is external). J Biol Chem. 286: 40184-92; 2011. Cited by Faculty of 1000 as a Recommended Article
  33. Murphy, E., Lagranha, C., Deschamps, A., Kohr, M., Nguyen, T., Wong, R., Sun, J., Steenbergen, C. Mechanism of cardioprotection: What can we learn from females?(link is external) Pediatr Cardiol. 32: 354-359; 2011.
  34. Wang, H., Viatchenko-Karpinski, S., Sun, J., Gyorke, I., Benkusky, N., Kohr, M.J., Valdivia, H., Murphy, E., Gyorke, S., Ziolo, M. Regulation of myocyte contraction via neuronal nitric oxide synthase: role of ryanodine receptor S-nitrosylation(link is external). J Phys. 588:2905-2917; 2010.
  35. Kohr, M.J., Traynham, C.J., Roof, S.R., Davis, J.P., Ziolo, M.T. cAMP-independent activation of protein kinase A by the peroxynitrite generator SIN-1 elicits positive inotropic effects in cardiomyocytes(link is external). J Mol Cell Cardiol. 45:645-648; 2010.
  36. Kohr, M.J., Kaludercic, N., Tocchetti, C.G., Gao, W.D., Kass, D.A., Janssen, P.M, Paolocci, N., Ziolo, M.T. Nitroxyl enhances cardiomyocyte Ca2+ transients by exclusively targeting sarcoplasmic reticulum Ca2+-cycling(link is external). Front in Biosci. E2:614-626; 2009.
  37. Wang, H., Kohr, M.J., Traynham, C.J. Ziolo, M.T. Phosphodiesterase Type 5 Restricts NOS3/Soluble Guanylate cyclase signaling to the L-type Ca2+ current(link is external). J Mol Cell Cardiol. 47: 304-314; 2009.
  38. Kohr, M.J., Davis, J.P., Ziolo, M.T. Peroxynitrite increases protein phosphatase activity and promotes the interaction of phospholamban with protein phosphatase 2a in the myocardium(link is external). Nitric Oxide. 20:217-221; 2009.
  39. Ziolo, M.T., Kohr, M.J., Wang, H. Nitric oxide signaling and the regulation of myocardial function(link is external). J Mol Cell Cardiol. 45:625-632; 2008.
  40. Wang, H., Kohr, M.J., Wheeler, D.G., Traynham, C.J., Janssen, P.M., Ziolo, M.T. Neuronal nitric oxide synthase signaling within cardiac myocytes targets phospholamban(link is external). Am J Physiol Cell Physiol. 294: C1566-1575; 2008.
  41. Kohr, M.J., Wang, H., Wheeler, D.G., Velayutham, M., Zweier, J.L., Ziolo, M.T. Biphasic effect of SIN-1 is reliant upon cardiomyocyte contractile state(link is external). Free Radic Biol and Med. 45:73-80; 2008.
  42. Wang, H., Kohr, M.J., Wheeler, D.G., Ziolo, M.T. Endothelial nitric oxide synthase decreases b-adrenergic responsiveness via inhibition of the L-type Ca2+ current(link is external). Am J Physiol Heart Circ Physiol. 294: H1473-1480; 2008.
  43. Kohr, M.J., Wang, H., Wheeler, D.G., Velayutham, M., Zweier, J.L., Ziolo, M.T. Targeting of phospholamban by peroxynitrite decreases b-adrenergic stimulation in cardiomyocytes(link is external). Cardiovasc Res. 77:353-361; 2008.
  44. Rosen, G.M., Burks, S.R., Kohr, M.J., Kao, J.P. Synthesis and biological testing of aminoxyls designed for long-term retention by living cells(link is external). Org Biomol Chem. 3: 645-648; 2005.