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Yukari Manabe

Departmental Affiliations

School of Medicine
Global Disease Epidemiology and Control

Contact Info

1830 E. Monument Street, Room 443

Research Interests

  • Infectious Diseases
Experiences & Accomplishments
Columbia University College of Physicians and Surgeons

Infectious Diseases Tuberculosis TB-HIV co-infection Immune Reconstitution Inflammatory Syndrome

Select Publications
  • -Manabe YC, Saviola BJ, Sun L, Murphy JR, Bishai WR. Attenuation of virulence in Mycobacterium tuberculosis expressing a constitutively active iron repressor. Proc Natl Acad Sci USA 1999; 96: 12844-12848. -Manabe YC, Chen JM, Ko CG, Chen P, Bishai Wr. Conditional Sigma Factor Expression, Using the Inducible Acetamidase Promoter, Reveals that the Mycobacterium tuberculosis sigF Gene Modulated the Expression of the 16kDa Alpha-Crystallin Homologue. J Bacteriol 1999; 181: 7629-7633. -Manabe YC, Scott CP, Bishai WR. Naturally attenuated, orally administered Mycobacterium microti as a tuberculosis vaccine better than subcutaneous M. bovis BCG. Infect Immun 2002; 70: 1566-70. -Kaushal D, Schroeder BG, Tyagi S, Yoshimatsu T, Scott C, Ko C, Carpenter L, Mehrotra J, Manabe YC, Fleischmann RD, Bishai WR. Reduced immunopathology and mortality despite tissue persistence in a Mycobacterium tuberculosis mutant lacking alternative sigma factor, SigH. Proc Natl Acad Sci USA 2002; 99: p8330-5. -Scott CP, dos Anjos Filho L, Carvalho de Queiroz Mello F, Thornton CG, Bishai WR, Fonseca LS, Kritski AL, Chaisson RE, Manabe YC. Comparison of C18-carboxypropylbetaine (CB-18) and standard NALC/NaOH processing of respiratory specimens for increasing tuberculosis smear sensitivity in an endemic, urban area. J Clin Micro 2002;40(9): p3219-3222. -Ando M, Manabe YC, Converse PJ, Miyazaki E, Harrison R, Murphy JR, Bishai, WR. Characterization of the role of the divalent metal ion-dependent transcriptional repressor MntR in the virulence of Staphylococcus aureus. Infect Immun 2003; 71(5): p2584-2590. -Manabe YC, Dannenberg AM Jr., Tyagi S, Hatem CL, Yoder M, Woolwine S., Zook BC, Pitt MLM, Bishai WR. Different Strains of Mycobacterium tuberculosis cause varied spectrums of disease in the rabbit model of tuberculosis. Infect Immun 2003; 71(10): p6004-11. -Scott CP, Kumar N, Bishai WR, Manabe YC. Plasmodium infection modulates Mycobacterium tuberculosis infection in the murine model. Am J Trop Med & Hygiene 2004; 70(2):p144-148. -Dorman S, Hatem CL, Tyagi S, Aird K, Lopez-Molina J, Pitt MLM, Zook BC, Dannenberg, AM Jr., Bishai WR, Manabe YC. Susceptibility to tuberculosis: clues from studies with inbred and outbred New Zealand White rabbits. Infect Immun 2004; 72(3): 1700-1705. -Geiman DE, Kaushal D, Ko C, Tyagi SK, Manabe YC, Schroeder BG, Fleischmann RD, Morrison NE, Converse PJ, Chen P, Bishai WR. Attenuation of late-stage disease in mice infected by the M. tuberculosis mutant lacking the SigF alternate sigma factor and identification of SigF-dependent genes by microarray analysis. Infect Immun 2004; 72(3):p1733-1745. -Manabe YC, Hatem CL, Kumar A, Durack J, Murphy JR. Corynebacterium diphtheriae DtxR(E175K) and Mycobacterium tuberculosis IdeR(D177K) are both dominant positive repressors of IdeR-regulated genes in Mycobacterium tuberculosis. Infect Immun 2005; 73(9):5988-94. -Kesavan AK, Mendez SE, Hatem CL, Lopez-Molina J, Aird K, Pitt MLM, Dannenberg AM, Jr., Manabe YC. Effects of Dexamethasone and Transient Malnutrition on Rabbits Infected by Aerosolized Mycobacterium tuberculosis CDC1551 Infect Immun 2005; 73(10): 7056-60. -Page KR, Jedlicka AE, Fakheri B, Noland GS, Kesavan AK, Scott AL, Kumar N, Manabe YC. Tuberculosis-Induced Type 1 Immune Response Reduces Mortality to P. yoelii Challenge in C57BL/6 but not BALB/c Mice Infect Immun 2005; 73(12):8369-80. -Tufariello JM, Mi K, Xu J, Manabe YC, Kesavan AK, Drumm J, Tanaka K, Chan J. Deletion of the Mycobacterium tuberculosis Resuscitation Promoting Factor Rv1009 Results in Delayed Reactivation from Chronic Tuberculosis Infect Immun 2006; 74(5):2985-95. -Karakousis PC, Sifakis FG, Montes de Oca R, Amarosa VC, Page KR, Manabe YC, Campbell JD. U.S. medical resident familiarity with national tuberculosis guidelines BMC Infectious Diseases 2007: Aug 2;7(1):89. -Manabe YC, Campbell JD, Sydnor ES, Moore RD. Immune Reconstitution Inflammatory Syndrome: Risk Factors and Treatment Implications J AIDS 2007 Dec 1;46(4):456-62 -Mendez S, Hatem CL, Kesavan AK, Lopez-Molina J, Pitt MLM, Dannenberg AM, Jr., Manabe YC. Further Studies in Inbred and Outbred New Zealand White Rabbits: Cellular Composition of Tuberculous Granulomas and Implications for Disease Containment. Vet Immunol Immunopathol. 2008 Mar 15;122(1-2):167-74. Epub 2007 Nov17. -Manabe YC, Kesavan AK, Lopez-Molina J, Hatem CL, Brooks M, Fujiwara R., Hochstein K, Pitt MLM, Tufariello J, Chan J, McMurray DN, Dannenberg AM, Jr., Mendez S. The aerosol rabbit model of tuberculosis latency, reactivation and immune reconstitution inflammatory syndrome. Tuberculosis 2008;88(3):187-96. -Page KR, Manabe YC, Adelakun A, Federline L, Cronin W, Campbell JD, Dorman SE. Timing of therapy for latent tuberculosis infection among immigrants presenting to a U.S. public health clinic: a retrospective study. BMC Public Health 2008; 8:158. -Kesavan AK, Brooks M, Tufariello J, Chan J, Manabe YC. Tuberculosis genes expressed during persistence and reactivation in the resistant rabbit model. Tuberculosis 2009; 89(1): 17-21 Epub 2008, Oct 23. -Converse, PJ, Karakousis PC, Kesavan AK, Klinkenberg LG, Ly LH, Allen SS, Grosset JH, Jain SK, Lamichhane G, Manabe YC, McMurray DN, Nuermberger EL, Bishai WR. The role of the dosR/dosS two-component regulatory system in Mycobacterium tuberculosis virulence in three animal models Infect Immun. 2008 Dec 22. [Epub ahead of print]

Infectious Diseases Institute At Makerere University in Kampala Uganda
Fogarty Global Health Fellows Coordinating Center
HIV co-infections in Uganda: TB, Cryptococcus, and viral hepatitis
Tuberculosis Clinical Diagnostics Research Consortium Contract
Evaluation of the accuracy and optimal use of the Eiken TB LAMP test for TB diagnosis at point-of-care in an HIV-prevalent setting in Uganda
Center for Point-of-Care Technologies Research for Sexually Transmitted Diseases
Rapid TB Diagnostic for Peripheral Facilities in the Developing World
Operational Research for Cryptococcal antigen screening to improve ART survival
Risk Factors for death in hospitalized HIV-positive tuberculosis suspects
Afya Bora Consortium
HIV and Hepatocellular Carcinoma in Uganda: H2U Consortium