Departmental Affiliations
Center & Institute Affiliations
Contact Info
Research Interests
Epidemiology; randomized clinical trials; multicenter studies; asthma; uveitis; COPD
Experiences & Accomplishments
My primary interest is in the design, conduct, and analysis of multicenter clinical trials. Many of the trials we have completed are comparative effectiveness trials - head to head comparisons of competing treatment with patient-centered outcomes. Most of my experience has been in trials in ophthalmology and pulmonology (seeing and breathing!). I teach two classes on clinical trials at the School. We also offer an abbreviated course on Coursera.
A full list of my published public citations can be found at My Bibliography (you may have to copy link into browser:
http://www.ncbi.nlm.nih.gov/myncbi/browse/collection/48114164/?sort=date&direction=descending
Select Publications
The old adage about asking if a tree falls in the forest, does it make a sound, is more true for randomized clinical trials than trees. Without publication in some form, the results of a clinical trial will have no effect on healthcare. Hence, publication regardless of the results is an essential component of the RCT process. The publications below are selected from multicenter clinical trials conducted by the two groups of researchers I have worked with the most, the American Lung Association's Airways Clinical Research Centers (ACRC) and the Uveitis Research Group. They report both positive and null results, and all are of trials of the use of approved therapies in clinical care.
Holbrook JT, Wise RA, Gold BD, Blake K, Brown ED, Castro M, Dozor AJ, Lima JJ, Mastronarde JG, Sockrider MM, Teague WG. Lansoprazole for children with poorly controlled asthma: a randomized controlled trial. JAMA. 2012 Jan 25;307(4):373-81. doi: 10.1001/jama.2011.2035. PMID: 22274684; PMCID: PMC4153372.
Thorne JE, Sugar EA, Holbrook JT, Burke AE, Altaweel MM, Vitale AT, Acharya NR, Kempen JH, Jabs DA; Multicenter Uveitis Steroid Treatment Trial Research Group. Periocular Triamcinolone vs. Intravitreal Triamcinolone vs. Intravitreal Dexamethasone Implant for the Treatment of Uveitic Macular Edema: The PeriOcular vs. INTravitreal corticosteroids for uveitic macular edema (POINT) Trial. Ophthalmology. 2019 Feb;126(2):283-295. doi: 10.1016/j.ophtha.2018.08.021. Epub 2018 Sep 27. PMID: 30269924; PMCID: PMC6348060.
Holbrook JT, Sugar EA, Brown RH, Drye LT, Irvin CG, Schwartz AR, Tepper RS, Wise RA, Yasin RZ, Busk MF; American Lung Association Airways Clinical Research Centers. Effect of Continuous Positive Airway Pressure on Airway Reactivity in Asthma. A Randomized, Sham-controlled Clinical Trial. Ann Am Thorac Soc. 2016 Nov;13(11):1940-1950. doi: 10.1513/AnnalsATS.201601-043OC. PMID: 27398992; PMCID: PMC5122477.
Tomkins-Netzer O, Lightman SL, Burke AE, Sugar EA, Lim LL, Jaffe GJ, Altaweel MM, Kempen JH, Holbrook JT, Jabs DA; Multicenter Steroid Treatment Trial and Follow-up Study Research Group. Seven-Year Outcomes of Uveitic Macular Edema: The Multicenter Uveitis Steroid Treatment Trial and Follow-up Study Results. Ophthalmology. 2021 May;128(5):719-728. doi: 10.1016/j.ophtha.2020.08.035. Epub 2020 Sep 10. PMID: 32918964; PMCID: PMC7943640.
Wise RA, Holbrook JT, Brown RH, Criner GJ, Dransfield MT, Han MK, Krishnan JA, Looney E, Neptune E, Palombizio V, Rea A. Losartan Effects on Emphysema Progression Randomized Clinical Trial: Rationale, Design, Recruitment, and Retention. Chronic Obstr Pulm Dis. 2021 Oct 28;8(4):414-426. doi: 10.15326/jcopdf.2021.0210. PMID: 34339598; PMCID: PMC8686851.
Wise RA, Holbrook JT, Brown RH, Criner GJ, Dransfield MT, He J, Henderson RJ, Kaminsky DA, Kaner RJ, Lazarus SC, Make BJ, McCormack MC, Neptune ER, Que LG. Clinical Trial of Losartan for Pulmonary Emphysema: Pulmonary Trials Cooperative Losartan Effects on Emphysema Progression Clinical Trial. Am J Respir Crit Care Med. 2022 Oct 1;206(7):838-845. doi: 10.1164/rccm.202201-0206OC. PMID: 35649189.