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Janet
Holbrook
,
PhD

Professor
Janet Holbrook

Departmental Affiliations

Primary
Division
Clinical Trials and Evidence Synthesis

Contact Info

415 N. Washington Street, 2nd Floor
Baltimore
Maryland
21231
US        
775-269-0836

Research Interests

Epidemiology; randomized clinical trials; multicenter studies; asthma; uveitis; COPD
Experiences & Accomplishments
Education
PhD
Johns Hopkins University
1999
MPH
University of California, Berkeley
1987
MS
University of Maryland
1983
BA
University of Maryland
1980
Overview
My primary interest is in the design, conduct, and analysis of multicenter clinical trials.  Many of the trials we have completed are comparative effectiveness trials - head to head comparisons of competing treatment with patient-centered outcomes. Most of my experience has been in trials in ophthalmology and pulmonology (seeing and breathing!). I teach two classes on clinical trials at the School. We also offer an abbreviated course on Coursera. A full list of my published public citations can be found at My Bibliography (you may have to copy link into browser: http://www.ncbi.nlm.nih.gov/myncbi/browse/collection/48114164/?sort=date&direction=descending
Select Publications
  • Holbrook JT, Wise RA, Gold BD, Blake K, Brown ED, Castro M, Dozor AJ, Lima JJ, Mastronarde JG, Sockrider MM, Teague WG.  Lansoprazole for children with poorly controlled asthma: a randomized clinical trial.  in Children with Asthma.  JAMA 2012; 307(4): 1-9.

  • Holbrook JT, Kempen JH, Prusakowski NA, Altawel MM, Jabs DA.  Challenges in the design and implementation of The Multicenter Uveitis Steroid Treatment (MUST) Trial – Lessons for Comparative Effectiveness Trials.  Clinical Trials 2011;8(6):736-743.

  • Kempen JH, Altaweel MM, Holbrook JT, Jabs DA, Louis TA, Sugar EA, Thorne JE. Randomized comparison of systemic anti-inflammatory therapy versus flucinolone actinide intraocular implant for intermeadiate, posterior and panuveitis: The Multicenter Uveitis Treatment Trial.  Ophthalmology 2011;118(10):736-743.

  • Holbrook JT, Colvin R, Van Natta ML, Thorne JE, Bardsley M, Jabs DA.  Evaluation of the United States Public Health Service guidelines for discontinuation of anti-CMV therapy after immune recovery in patients with CMV retinitis.  Am J Ophthalmology 2011;142(4):628-637.

  • Multicenter Uveitis Steroid Treatment (MUST) Trial Research Group. The MUST Trial: rational, design and baseline characteristics. 2010;149:550-561.

Projects
Multicenter Uveitis Steroid Treatment (MUST) Trial