Rakai Health Sciences Program, HIV, HIV prevention, HPV, male circumcision, sexually transmitted infections, population-based cohort study
Experiences & Accomplishments
Co-founded, with Drs. David Serwadda and Nelson Sewankambo, the Rakai Health Sciences Program (RHSP), Rakai District, Uganda. Since 1988, the RHSP has conducted population-based cohort studies on HIV and related infections including malaria, HPV, HSV-2, BV and other STIs; behavioral risk factors; HIV/STI individual and community -randomized prevention trials; operations research on HIV and reproductive health service provision; molecular epidemiology of HIV, effects of HIV subtypes, and HIV superinfection; HIV/STI care and treatment; and social, familial and demographic consequences of HIV. Trials have included STI control for HIV prevention, STI control during pregnancy for the prevention of mother-to-child HIV transmission, male circumcision for HIV prevention in men and male circumcision in HIV+ men for the prevention of HIV/STI transmission to women. Current interests also include the role of mucosal immunity and the genital biome in resistance/susceptibility to HIV infection.
Reynolds SJ, Makumbi F, Newell K, Kiwanuka N, Ssebbowa P, Mondo G, Boaz I, Wawer MJ, Gray RH, Serwadda D, Quinn TC. Effect of daily acyclovir on HIV disease progression in individuals in Rakai, Uganda, co- infected with HIV-1 and herpes simplex virus type 2: a randomised, double-blind placebo-controlled trial. Lancet Infect Dis. 2012 Mar 17. [Epub ahead of print]
Tobian AA, Kigozi G, Gravitt PE, Xiao C, Serwadda D, Eaton KP, Kong X, Wawer MJ, Nalugoda F, Quinn TC, Gray RH. Human papillomavirus incidence and clearance among HIV-positive and HIV-negative men in Rakai, Uganda. AIDS. 2012 Mar 23. [Epub ahead of print]
Wawer MJ, RH Gray. Challenges in assessing associations between hormonal contraceptive use and the risks of HIV-1 acquisition and transmission. Future MIcrobiology, 2012, March: 7: 315-8.
Prodger JL, Gray R, Kigozi G, Nalugoda F, Galiwango R, Kakanga M, Hirbod T, Wawer MJ, Sewankambo N, Serwadda D, Kaul R; the Rakai Genital Immunology Research Group. Impact of asymptomatic Herpes simplex virus-2 infection on T cell function in the foreskin of men from Rakai, Uganda. AIDS. 2012 Apr 21. [Epub ahead of print]
Gray R, Kigozi G, Kong X, Ssempiija V, Makumbi F, Wattya S, Serwadda D, Nalugoda F, Sewenkambo NK, Wawer MJ. The effectiveness of male circumcision for HIV prevention and effects on risk behaviors in a post-trial follow-up study in Rakai, Uganda. AIDS. 2012 Jan 4. [Epub ahead of print]