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Senior Scientist
Maria Knoll

Departmental Affiliations

Global Disease Epidemiology and Control

Center & Institute Affiliations

Maria Deloria Knoll, PhD ’00, designs, conducts, and analyzes policy-driven epidemiological studies and clinical trials evaluating vaccines and vaccine-preventable diseases.

Contact Info

415 N. Washington Street, Room 549

Research Interests

vaccines; international health; COVID-19/SARS-CoV-2; S. Pneumoniae; H. influenzae; RSV; meningococcus; HPV; pertussis; pneumonia; meningitis; vaccine preventable diseases; epidemiology; clinical trials; meta-analysis; pneumonia etiology; disease burden; vaccine impact; pneumococcal conjugate vaccine
Experiences & Accomplishments
Johns Hopkins University
University of North Carolina, Chapel Hill
As the Director of Epidemiology for IVAC (International Vaccine Access Center), I focus on policy-driven research evaluating vaccines and vaccine-preventable diseases.

Projects include: Assessing factors associated with COVID-19 disease and transmission in Maryland households; global tracking and review of COVID-19 vaccine effectiveness to support WHO and CEPI; evaluating the impact of introducing pneumococcal conjugate vaccine (PCV) into childhood national immunization programs on pneumococcal disease, including the indirect effects on adults; synthesizing evidence through meta-analytical and modeling approaches to estimate global disease burden, serotype distribution and vaccine impact globally for pneumococcal, Hib, meningococcal and pertussis disease among children and adults; evaluating impact of vaccine dosing schedule, age at immunization and product choice to inform WHO policy recommendations and country decision-making regarding vaccine introduction; determining the causes of pneumonia in a 7-country pneumonia case-control study (PERCH) in developing-country settings to guide the development of new pneumonia vaccines and treatment algorithms; evaluating new diagnostic tools such as antigen-based blood tests and pneumococcal serotype-specific urine antigen tests to determine their sensitivity and specificity for detecting pneumococcal disease in pneumonia patients; developing and assessing digital tools to assist in the standardization of clinical findings of pneumonia, such as digital auscultation and computer automated chest x-ray interpretation. I also work on collaborative efforts with other Departments and Institutions to develop new analytical tools, such as an analytical method for estimating pneumonia etiology, and direct VIEW-hub, a publicly available and interactive data visualization platform displaying vaccine introduction, coverage, access, impact, and disease burden data globally.
Honors & Awards
National Institutes of Health Merit Award (1999,1991)
Food and Drug Administration Commissioner’s Special Citation Group Award (1997)
U.S. DHHS Secretary’s Group Award for Distinguished Service (1996)
U.S. DHHS Special Achievement Award (1995,1991)
Select Publications
Selected representative publications:
  • Deloria Knoll M, Bennett JC, Garcia Quesada M, Kagucia EW, Peterson ME, Feikin DR, Cohen AL, Hetrich MK, Yang Y, Sinkevitch JN, Ampofo K, Aukes L, Bacci S, Bigogo G, Brandileone M-CC, Bruce MG, Camilli R, Castilla J, Chan G, Chanto Chacón G, Ciruela P, Cook H, Corcoran M, Dagan R, Danis K, de Miguel S, De Wals P, Desmet S, Galloway Y, Georgakopoulou T, Hammitt LL, Hilty M, Ho P-L, Jayasinghe S, Kellner JD, Kleynhans J, Knol MJ, Kozakova J, Kristinsson KG, Ladhani SN, Lara CS, León ME, Lepp T, Mackenzie GA, Mad’arová L, McGeer A, Mungun T, Mwenda JM, Nuorti JP, Nzoyikorera N, Oishi K, De Oliveira LH, Paragi M, Pilishvili T, Puentes R, Rafai E, Saha SK, Savrasova L, Savulescu C, Scott JA, Scott KJ, Serhan F, Setchanova LP, Sinkovec Zorko N, Skoczy?ska A, Swarthout TD, Valentiner-Branth P, van der Linden M, Vestrheim DF, von Gottberg A, Yildirim I, Hayford K, the PSERENADE Team. Global Landscape Review of Serotype-Specific Invasive Pneumococcal Disease Surveillance among Countries Using PCV10/13: The Pneumococcal Serotype Replacement and Distribution Estimation (PSERENADE) Project. Microorganisms. 2021; 9(4):742.
  • Deloria Knoll M, Prosperi C, Baggett HC, Brooks WA, Feikin DR, Hammitt LL, Howie SRC, Kotloff KL, Madhi SA, Murdoch DR, Scott JAG, Thea DM, O'Brien KL. Introduction to the Site-specific Etiologic Results From the Pneumonia Etiology Research for Child Health (PERCH) Study. Pediatr Infect Dis J. 2021 Sep 1;40(9S):S1-S6. doi: 10.1097/INF.0000000000002778. PubMed PMID: 34448739.
  • Wahl B, O’Brien KL, Greenbaum A, Liu L, Chu Y, Majumder A, Lukši? I, Nair H, McAllister DA, Campbell H, Rudan I, Black R, Knoll MD. Global, regional, and national burden of Streptococcus pneumoniae and Haemophilus influenzae type b in children in the era of conjugate vaccines: updated estimates from 2000-2015. Lancet Global Health 2018; 6: e744–e757.
  • Deloria Knoll M, Fu W, Shi Q, Prosperi C, Wu Z, Hammitt LL, Feikin DR, Baggett HC, Howie SRC, Scott JAG, Murdoch DR, Madhi SA, Thea DM, Brooks WA, Kotloff KL, Li M, Park DE, Lin W, Levine OS, O’Brien KL, Zeger SL. Bayesian estimation of pneumonia etiology: epidemiologic considerations and applications to pneumonia etiology research for child health study. Clin Infect Dis 2017; 64(suppl 3):S213–27.
  • Deloria Knoll M, Park DE, Johnson TS, Chandir S, Nonyane BA, Conklin L, Fleming-Dutra KE, Loo JD, Goldblatt D, Whitney CG, O'Brien KL. Systematic review of the effect of pneumococcal conjugate vaccine dosing schedules on immunogenicity. Pediatr Infect Dis J 2014;33 (Suppl 2):S119-29.
Developing Bayesian analytical approaches to estimation of pneumonia etiology
PREVAIL: Pneumonia Research and Vaccine Impact League
PCV Technical Coordination with WHO
Hib and pneumococcal disease burden estimation in China
Maternal and Child Epidemiology Estimation (MCEE) collaboration: Global and national pneumococcal, Hib and pertussis etiology estimates
Sustaining Access for Vaccines in India (SAVI)
Baltimore City Influenza Vaccine Initiative Evaluation
PCV Impact in Nepal
SEARCh: SARS-CoV-2 household transmission in Maryland
VIEW-Hub: website tracking globally vaccine introduction, coverage and impact studies
PERCH: etiology of pneumonia in 7 African and Asian countries
COVID-19 Vaccine Effectiveness: global review
Global Impact of PCV on invasive pneumococcal disease in all ages (PSERENADE)