Departmental Affiliations
Research Interests
Environmental and occupational health sciences; molecular biomonitoring; genotoxic agents; carcinogens; genetic polymorphisms; carcinogen metabolites; genetic damage in human populations; molecular epidemiology; exposome
Experiences & Accomplishments
Education
PhD
New York University
1978
MSc
New York University
1974
Overview
Our research focuses on molecular biomonitoring of toxic agents and genetic polymorphisms associated with their metabolism. The general theme is the assessment of toxicant metabolites and early effects in human populations with known or suspected exposure to various occupational or environmental toxicants. This approach has widespread application in assessing previous exposure to carcinogens and other toxicants and is used as a predictor of ultimate disease risk. The ability to measure toxicant metabolites and early effects in human tissues allows one to address a variety of public health issues related to the human exposome and individual susceptibility to environmental diseases. Furthermore, elucidating the spectrum of common polymorphisms in toxicant metabolizing and other genes associated with disease outcome provides an approach to assessing individual susceptibility to disease.
Honors & Awards
International Agency for Research on Cancer Fellow (UK); Dale Research Fellow (Paterson Laboratories, UK); Mellon Foundation Fellow (Johns Hopkins University); Howard Fox Lecture, New York University Medical Center, New York; Keynote Lecture, International Symposium on Biological Monitoring, Seoul, Korea; Keynote Lecture, International Symposium on Occupational Health, Bangkok, Thailand
Select Publications
Selected Publications from the last 5 years.
- Etemadi A, Islami F, Phillips DH, Godschalk R, Golozar A, Kamangar F, Malekshah AF, Pourshams A, Elahi S, Ghojaghi F, Strickland PT, Taylor PR, Boffetta P, Abnet CC, Dawsey SM, Malekzadeh R, van Schooten FJ. Variation in PAH-related DNA adduct levels among non-smokers: The role of multiple genetic polymorphisms and nucleotide excision repair phenotype. Int J Cancer 2013; 132:2738-47. PMID: 23175176; PMCID: PMC3597757.
- Alberg AJ, Jorgensen TJ, Ruczinski I, Wheless L, Shugart YY, Berthier-Schaad Y, Kessing B, Hoffman-Bolton J, Helzlsouer KJ, Kao WH, Francis L, Alani RM, Smith MW, Strickland PT. DNA repair gene variants in relation to overall cancer risk: a population-based study. Carcinogenesis 2013; 34:86-92. PMID: 23027618; PMCID: PMC3534189.
- Islami F, Boffetta P, van Schooten FJ, Strickland P, Phillips DH, Pourshams A, Fazel-Tabar Malekshah A, Godschalk R, Jafari E, Etemadi A, Abubaker S, Kamangar F, Straif K, Møller H, Schüz J, Malekzadeh R. Exposure to Polycyclic Aromatic Hydrocarbons Among Never Smokers in Golestan Province, Iran, an Area of High Incidence of Esophageal Cancer - a Cross-Sectional Study with Repeated Measurement of Urinary 1-OHPG in Two Seasons. Front Oncol. 2012;2:14. PubMed PMID: 22655262; PubMed Central PMCID: PMC3356003.
- Hofmann JN, Liao LM, Strickland PT, Shu XO, Yang G, Ji BT, Li HL, Rothman N, Kamangar F, Gao YT, Zheng W, Chow WH. Polycyclic aromatic hydrocarbons: determinants of urinary 1-hydroxypyrene glucuronide concentration and risk of colorectal cancer in the Shanghai Women's Health Study. BMC Cancer. 2013 Jun 11;13:282. doi: 10.1186/1471-2407-13-282. PubMed PMID: 23758680; PubMed Central PMCID: PMC3686696.
- Peters KO, Williams DL, Abubaker S, Curtin-Brosnan J, McCormack MC, Peng R, Hansel NN, Breysse PN, Matsui EC, Diette GB, Strickland PT. Predictors of polycyclic aromatic hydrocarbon exposure and internal dose in inner city Baltimore children. J Expos Sci Environ Epidemiol. 2016.?Dec 14. doi: 10.1038/jes.2016.57. [Epub ahead of print]
Projects
Role of polycyclic aromatic hydrocarbons (PAH) in Esophageal Cancer in High Risk Areas