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Marcelo
Jacobs-Lorena
,
PhD

Professor

Contact Info

615 N. Wolfe Street, Room E4632
Baltimore
Maryland
21205
US        
410-955-0105

Research Interests

malaria; mosquitoes; transgenesis; Plasmodium-mosquito interacions; peritrophic matrix
Experiences & Accomplishments
Education
MSc
Osaka University
1967
PhD
Massachusetts Institute of Technology
1972
Overview
Mosquitoes as Vectors for the Malaria Parasite Our research covers four topics: o Genetic modification of mosquito vectorial capacity o Mosquito-Plasmodium interactions o Gene expression during Plasmodium development in the mosquito o Structure and function of the peritrophic matrix (PM)
Select Publications
  • Srinivasan P, Coppens I and Jacobs-Lorena M (2008) Distinct roles of Plasmodium Rhomboid 1 in parasite development and malaria pathogenesis. PLoS Pathogens 5(1) e1000262.

  • Ghosh AK, Devenport M, Jethwaney D, Kalume DE, Pandey A, Anderson VE, Sultan AA, Kumar N and Jacobs-Lorena M (2008) Malaria parasite invasion of the mosquito salivary gland requires interaction between the Plasmodium TRAP and the Anopheles saglin proteins. PLoS Pathogens, 5(1)e1000265.

  • Dinglasan RR, Devenport M, Florens L, Johnson JR, McHugh CA, Donnelly-Doman, M, Carucci DJ, Yates JR. III and Jacobs-Lorena, M (2008) The Anopheles gambiae adult midgut peritrophic matrix proteome. Insect Biochem. Mol. Biol, in press.

  • Srinivasan P, Fujioka H and Jacobs-Lorena M (2008) PbCap380, a novel oocyst capsule protein, is essential for malaria parasite survival in the mosquito. Cell. Microbiol. 10:1304-1312.

  • Li C, Marrelli MT, Yan G and Jacobs-Lorena M (2008) Fitness of transgenic Anopheles stephensi mosquitoes expressing the SM1 peptide under the control of a vitellogenin promoter. J. Hered. 99:275-282.

Projects
Analysis of Plasmodium Development in the Mosquito
Create New Tools to Accelerate the Eradication of Malaria: Using Bacteria to Contain the Spread of Malaria
Mechanisms of mosquito midgut invasion by Plasmodium ookinetes
Using Bacteria to Contain the Spread of Malaria
Vector Biology Using Mosquito Pathogen as a Delivery System for Anti-Malarial