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Marcelo
Jacobs-Lorena
,
PhD

Professor

Contact Info

615 N. Wolfe Street, Room E4632
Baltimore
Maryland
21205
US        
410-955-0105

Research Interests

malaria; mosquitoes; transgenesis; Plasmodium-mosquito interacions; peritrophic matrix
Experiences & Accomplishments
Education
MSc
Osaka University
1967
PhD
Massachusetts Institute of Technology
1972
BA
São Paulo University, Brazil
1964
Overview
Mosquitoes as Vectors for the Malaria Parasite
Our research covers four topics:
o Genetic modification of mosquito vectorial capacity o Mosquito-Plasmodium interactions o Gene expression during Plasmodium development in the mosquito o Structure and function of the peritrophic matrix (PM)
Select Publications
  • Srinivasan P, Coppens I and Jacobs-Lorena M (2008) Distinct roles of Plasmodium Rhomboid 1 in parasite development and malaria pathogenesis. PLoS Pathogens 5(1) e1000262.

  • Ghosh AK, Devenport M, Jethwaney D, Kalume DE, Pandey A, Anderson VE, Sultan AA, Kumar N and Jacobs-Lorena M (2008) Malaria parasite invasion of the mosquito salivary gland requires interaction between the Plasmodium TRAP and the Anopheles saglin proteins. PLoS Pathogens, 5(1)e1000265.

  • Dinglasan RR, Devenport M, Florens L, Johnson JR, McHugh CA, Donnelly-Doman, M, Carucci DJ, Yates JR. III and Jacobs-Lorena, M (2008) The Anopheles gambiae adult midgut peritrophic matrix proteome. Insect Biochem. Mol. Biol, in press.

  • Srinivasan P, Fujioka H and Jacobs-Lorena M (2008) PbCap380, a novel oocyst capsule protein, is essential for malaria parasite survival in the mosquito. Cell. Microbiol. 10:1304-1312.

  • Li C, Marrelli MT, Yan G and Jacobs-Lorena M (2008) Fitness of transgenic Anopheles stephensi mosquitoes expressing the SM1 peptide under the control of a vitellogenin promoter. J. Hered. 99:275-282.

Projects
Create New Tools to Accelerate the Eradication of Malaria: Using Bacteria to Contain the Spread of Malaria
Mechanisms of mosquito midgut invasion by Plasmodium ookinetes
Using Bacteria to Contain the Spread of Malaria
Vector Biology Using Mosquito Pathogen as a Delivery System for Anti-Malarial