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Assistant Professor

Jotham Suez, PhD, MSc, studies the microbiome and the mechanisms through which symbiotic bacteria, viruses, and fungi shape the health of their human host.

Contact Info

Research Interests

Microbiome; Microbial ecology; Precision / Personalized medicine; Metabolism; Metabolic syndrome; Diabetes; Obesity; Antibiotics; Antibiotics resistance; Probiotics; Fecal microbiome transplantation (FMT)
Experiences & Accomplishments
Weizmann Institute of Science
Tel Aviv University
Tel Aviv University
The human body is inhabited by trillions of bacteria, viruses and eukaryotic microorganisms, collectively termed the microbiome. This microbial community plays critical roles in health and disease.
To understand the mechanisms involved and improve health, we ask how microbes interact with…

The microbiome serves as a nexus between the host and environmental exposures, including nutrients, drugs, and other xenobiotics. Metabolism of these substrates by the microbiome can result in molecules that are beneficial or detrimental for the host. At the same time, environmental stimuli can directly affect on the microbial community, which may lead to a disease-promoting configuration. We take a metabolomic approach to understand the outcome of interactions between microbes and environmental stimuli.

Microbes in the gut interact with other members of the community, and disease can occur when balance is disrupted. They can also interact with exogenous microbes, which can be pathogenic or of potential therapeutic value. The resident microbes can resist colonization with exogenous ones, potentially compromising efficacy of therapeutics such as probiotics and fecal microbiome transplantation. In parallel, therapeutic bacteria may have unexpected effects on the microbiome. We take a microbial ecology approach to understand the forces that shape the microbial community and the mechanisms through which bacteria, viruses, and fungi interact within the host.

Interactions among microbes and between the microbiome and environmental stimuli do not occur in a void, and we are interested in those interactions that help maintain our health or promote disease. We are currently looking at how these tripartite host-microbiome-environment interactions mediate pathogenesis of metabolic syndrome and inflammatory bowel diseases. To that end, we couple multi-omics analysis of the microbiome and the host with in vivo models and clinical trials.
Honors & Awards
NIH Director's Early Independence Award, 2020
Select Publications
Selected publications:
  • Suez J, Zmora N, Zilberman-Schapira G, Mor U, Dori-Bachash M, Bashiardes S, Zur M, Regev-Lehavi D, Ben-Zeev Brik R, Federici S, Horn M, Cohen Y, Moor AE, Zeevi D, Korem T, Kotler E, Harmelin A, Itzkovitz S, Maharshak N, Shibolet O, Pevsner-Fischer M, Shapiro H, Sharon I, Halpern Z, Segal E, Elinav E. Post-Antibiotic Gut Mucosal Microbiome Reconstitution Is Impaired by Probiotics and Improved by Autologous FMT. Cell. 2018 Sep 6;174(6):1406-1423.e16. PubMed PMID: 30193113.
  • Montassier E, Valdés-Mas R, Batard E, Zmora N, Dori-Bachash M, Suez J, Elinav E. Probiotics impact the antibiotic resistance gene reservoir along the human GI tract in a person-specific and antibiotic-dependent manner. Nature Microbiology. 2021 Aug;6(8):1043-54. PubMed PMID: 34226711.
  • Suez J, Korem T, Zeevi D, Zilberman-Schapira G, Thaiss CA, Maza O, Israeli D, Zmora N, Gilad S, Weinberger A, Kuperman Y, Harmelin A, Kolodkin-Gal I, Shapiro H, Halpern Z, Segal E, Elinav E. Artificial sweeteners induce glucose intolerance by altering the gut microbiota. Nature. 2014 Oct 9;514(7521):181-6. PubMed PMID: 25231862.
  • Harrington V, Lau L, Seddu K, Suez J. Ecology and Medicine Converge at the Microbiome-Host Interface. Msystems. 2021 Aug 31;6(4):e00756-21. PubMed PMID: 34463567.
  • Zmora N, Zilberman-Schapira G, Suez J, Mor U, Dori-Bachash M, Bashiardes S, Kotler E, Zur M, Regev-Lehavi D, Brik RB, Federici S, Cohen Y, Linevsky R, Rothschild D, Moor AE, Ben-Moshe S, Harmelin A, Itzkovitz S, Maharshak N, Shibolet O, Shapiro H, Pevsner-Fischer M, Sharon I, Halpern Z, Segal E, Elinav E. Personalized Gut Mucosal Colonization Resistance to Empiric Probiotics Is Associated with Unique Host and Microbiome Features. Cell. 2018 Sep 6;174(6):1388-1405.e21. PubMed PMID: 30193112.