Mosquito-pathogen interaction; Mosquito-borne diseases; Mosquito genome editing and transgenic; Vector biology and control
Experiences & Accomplishments
Mosquito vectors transmit a broad range of human viral and parasitic diseases and over one million people worldwide die from mosquito-borne diseases every year. Current measures to control arthropod-borne diseases and their mosquito vectors are insufficient partially due to the lack of sustainable vector control strategies and vaccines. The overall goal of my research interests is to study the molecular biology and genomics of mosquitoes and mosquito-pathogen interactions, leading to the development of novel control strategies for vector-borne diseases.
Dong S, Dimopoulos G, 2023. Aedes aegypti Argonaute 2 controls arbovirus infection and host mortality. Nature Communications: 14, 5773.
Dong Y#, Dong S#, Dizaji NB, Rutkowski N, Pohlenz T, Myles K, Dimopoulos G, 2022. The Aedes aegypti siRNA pathway mediates broad-spectrum defense against human pathogenic viruses and modulates antibacterial and antifungal defenses. PLoS Biology: e3001668. (# Co-first author)
Dong S, Dong Y, Simoes ML, Dimopoulos G, 2022. Mosquito transgenesis for malaria control. Trends Parasitol, 38:54-66.
Dong S, Ye Z, Tikhe C, Tu Z, Zwiebel L, Dimopoulos G, 2021. Pleiotropic odorant-binding proteins promote Aedes aegypti reproduction and flavivirus transmission. mBio, 12:e02531-21.
Dong S, Fu X, Dong Y, Simoes ML, Zhu J, Dimopoulos G, 2020. Broad spectrum immunomodulatory effects of Anopheles gambiae microRNAs and their use for transgenic suppression of Plasmodium. PloS Pathogens 16:e1008453.