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Assistant Scientist

Maggie Wear, PhD, MS, studies fungal polysaccharides and catalytic antibodies in the lab and teaches critical thinking and social justice in science.

Contact Info

615 N Wolfe St, E5622

Research Interests

polysaccharide; yeast; NMR; structure; catalytic antibody; cryptococcus neoformans
Experiences & Accomplishments
Uniformed Services University of the Health Sciences
Irell & Manella Graduate School of Biomedical Sciences
St. Mary's College of Maryland
Dr. Maggie Wear is an Instructor in the MMI Department and an Assistant Scientist in the laboratory of Dr. Arturo Casadevall where she has a few focuses; the biochemical and structural attributes of antibodies possessing catalytic activity, the Cryptococcus neoformans pathogenic fungi polysaccharide capsule structure and function, the types of yeast and their role in cocoa fermentation focusing on flavinoid and glycoside hydrolase secretion, and helping to educate the next generation of scientists.

While in graduate school she began teaching at the undergraduate level focusing on laboratory exercises and encouraging students to connect what they learned in lectures, and from textbooks, to hands on wet bench experiments in chemistry and molecular biology. With a passion for scientific education, Dr. Wear began working in the "R3" Science Education Initiative in 2016. Her interests center around the practical applications of critical and philosophical thinking in graduate scientific education and mentoring. With curiosity and depth of understanding as driving forces, her scientific discussions often result in a Socratic-like questioning of the data and reasoning behind a scientific conclusion.

Originally from Detroit, Michigan, Dr. Wear holds a Master's Biomedical Sciences from the Beckman Research Institute at City of Hope in California, and a Ph.D. in Biochemistry from Uniformed Services University in Bethesda, Maryland. Her Post-Doctoral work was done at Johns Hopkins School of Public Health in the Molecular Microbiology and Immunology department.
Honors & Awards
Delta Omega Innovative Public Health Curriculum Award 2020 For “Implementing Community-Based Practice Through Civic Engagement Projects”

SOURCE Service Learning Fellow 2020-2021 Development of online service learning course “Implementing Community-Based Practice Through Civic Engagement Projects”

Invited Seminar Speaker: 2017 “Catalytic Antibodies Targeting Glycans & Glycoproteins in Infection and Immunity” Johns Hopkins School of Medicine Glycobiology Interest Group

Invited Oral presentation: 2017 “Structural analysis of synthetic oligomer of Cryptococcus neoformans polysaccharide capsule” American Chemical Society National Meeting; Carbohydrate Chemistry section
Select Publications
Most recent publications
  • Critical online service-learning pedagogy: Justice in science education RT Derreth, MP Wear Journal of Microbiology & Biology Education 22 (1), ev22i1. 2537
  • A glycan FRET assay for detection and characterization of catalytic antibodies to the Cryptococcus neoformans capsule CJ Crawford, MP Wear, DFQ Smith, C d’Errico, SA McConnell, ... Proceedings of the National Academy of Sciences 118 (5)
  • Hinge Influences in Murine IgG Binding to Cryptococcus neoformans Capsule DSL de Oliveira, V Paredes, AV Caixeta, NM Henriques, MP Wear, ... bioRxiv
  • Antibodies to the Cryptococcus neoformans Capsule have Innate Glycosidase Activity C Crawford, MP Wear, DFQ Smith, C d'Errico, A Casadevall, S Oscarson
  • Exploring Cryptococcus neoformans capsule structure and assembly with a hydroxylamine-armed fluorescent probe CJ Crawford, RJB Cordero, L Guazzelli, MP Wear, A Bowen, S Oscarson, ... Journal of Biological Chemistry 295 (13), 4327-4340
Cryptococcal Polysaccharide Structural Characterization
Characterization of Antibody Catalytic Activity and its Consequences
Investigating the yeast species involved in hawaiian cocoa fermentation