Departmental Affiliations
Affiliated
Center & Institute Affiliations
Research Interests
Chronic kidney disease;Gout;Serum Urate;GSTM1;metabolomics
Experiences & Accomplishments
Education
PhD
Johns Hopkins Bloomberg School of Public Health
2012
MS
New Jersey Institute of Technology
2004
Overview
Dr. Tin’s research focuses on increasing our understanding on the genetic and non-genetic susceptibility for chronic kidney disease (CKD) and related traits and to identify novel targets for prevention and treatment. Chronic diseases are consequences of genetic susceptibility and environmental exposure. Dr. Tin uses a multilevel approach that combines genomic information (DNA sequence variation, DNA methylation, and gene expression) with clinical and metabolomics information from population-based studies. This integrated approach can identify intermediary factors that are at the intersection of genetic susceptibility and environmental exposure and link the biological pathways in the pathogenesis of a disease. Increasing our understanding of these intermediary factors and biological pathways can reveal potential prevention and treatment targets.
Honors & Awards
New Jersey Institute of Technology M.S. Program in Applied Statistics Assistantship, 2003.
Executive Women of New Jersey Graduate Merit Award, 2004.
The Inaugural W.H. Linda Kao Collaboration Award, 2014
Executive Women of New Jersey Graduate Merit Award, 2004.
The Inaugural W.H. Linda Kao Collaboration Award, 2014
Select Publications
Most recent first-authored publications
- Tin A*, Marten J*, Halperin Kuhns VL*, Li Y*, Wuttke M*, Kirsten H*, et al. Target genes, variants, tissues and transcriptional pathways influencing human serum urate levels. Nat Genet. 2019 Oct 2. PubMed PMID: 31578528. Epub 2019/10/04. eng.(* joint contribution)
- Tin A, Li Y, Brody JA, Nutile T, Chu AY, Huffman J. Large-Scale Whole-Exome Sequencing Association Studies Identify Rare Functional Variants Influencing Serum Urate Levels. Nat Comm 2018; 9:4228
- Tin A, Scharpf R, Estrella MM, et al. The Loss of GSTM1 Associates with Kidney Failure and Heart Failure. J Am Soc Nephrol 2017;28:3345-52.
- Chu AY*, Tin A*, Schlosser P, Ko YA, Qiu C, Yao C, et al. Epigenome-wide Association Studies Identify DNA Methylation Associated with Kidney Function. Nat Commun. 2017;8(1):1286. (* contributed equally)
- Tin A, Grams ME, Ashar FN, Lane JA, Rosenberg AZ, Grove ML, et al. Association between Mitochondrial DNA Copy Number in Peripheral Blood and Incident CKD in the Atherosclerosis Risk in Communities Study. J Am Soc Nephrol. 2016 Jan 21. PubMed PMID: 26794963. Epub 2016/01/23. Eng.