Departmental Affiliations
School of Medicine
Primary
Research Interests
hepatitis B; hepatitis C; HIV-viral hepatitis co-infection; hepatitis B cure, non-alcoholic fatty liver disease, maternal-fetal transmission hepatitis B
Experiences & Accomplishments
Education
MD
Yale University School of Medicine
1992
Overview
My lab focuses on chronic viral hepatitis including hepatitis B virus (HBV) and hepatitis C virus (HCV)in people with and without co-infection with HIV. For both of these viruses, some individuals can recover from the infection (with HCV they clear it but with HBV they suppress replication without medications) and some individuals have a chronic infection. Our overall goal for the HBV studies is to understand the immune response to HBV to aid in the development of a cure. Current studies include: 1) HBV virology in single hepatocytes from liver tissue obtained through laser capture microscopy, 2) T and B cell immune response to people acutely infected with HBV, 3) Developing a neutralizing antibody assay to study the antibody response to HBV, and 4) Using genome wide association stud (GWAS) data to find human genetic variants that are associated with HBV recovery or persistence. For our HCV studies we also use GWAS data to find host genetic variants associated with clearance or persistence. We are also looking at how HIV therapy alters the immune response to HCV in those with HIV-HCV co-infection.
Honors & Awards
Phi Beta Kappa, 1987
Recipient, Burroughs Wellcome Fund Pathogenesis in Infectious Diseases Award, 2000
Interurban Clinical Club, 2011
American Society of Clinical Investigation, 2008
Recipient, Burroughs Wellcome Fund Pathogenesis in Infectious Diseases Award, 2000
Interurban Clinical Club, 2011
American Society of Clinical Investigation, 2008
Select Publications
Selected Publications from the last 5 years
- 108. Vergara C, Thio CL, Johnson E, Kral AH, O'Brien TR, Goedert JJ, Mangia A, Piazzolla V, Mehta SH, Kirk GD, Kim AY, Lauer GM, Chung RT, Cox AL, Peters MG, Khakoo SI, Alric L, Cramp ME, Donfield SM, Edlin BR, Busch MP, Alexander G, Rosen HR, Murphy EL, Latanich R, Wojcik GL, Taub MA, Valencia A, Thomas DL, Duggal P. Multi-ancestry genome-wide association study of spontaneous clearance of hepatitis C virus. Gastroenterology 2019 Apr; 156(5):1496-1507.PMCID PMC6788806
- Price JC, Wang R, Seaberg EC, Brown TT, Budoff MJ, Kingley LA, Palella, FJ, Witt MD, Post WS, Lake JE, Thio CL. Sex hormone binding globulin levels are inversely associated with nonalcoholic fatty liver disease in HIV-infected and –uninfected men. OFID 2019 December,:6(12):ofz468. PMC7047947
- Balagopal A, Grudda T, Ribeiro RM, Saad YS, Hwang HS, Quinn J, Murphy M, Ward K, Sterling RK, Zhang Y, Perelson AS, Sulkowski MS, Osburn WO, Thio CL. Single hepatocytes show persistence and transcriptional inactivity of hepatitis B. JCI Insight 2020 Oct 5(19): 140584. PMCID: PMC7566712
- Irvin R, Gamble T, Malone J, Wang Z, Wilson E, Hughes JP, Farley J, Mayer KH, Del Rio C, Batey DS, Cummings V, Remien RH, Beyrer C, Thio CL. HTPN 078: High prevalence of HCV antibodies among urban US men who have sex with men (MSM) independent of HIV status. CID, in press Dec 2020.
- Falade-Nwulia O, Seaberg EC, Snider AE, Rinaldo CR, Wolinsky SM, Witt MD, Thio CL. Outcomes of acute hepatitis B virus (HBV) in HIV infection with and without HBV-active antiretroviral therapy. AIDS 2021 May; 35(6): 991-993.