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Philip
Jordan
,
PhD

Associate Professor
Philip Jordan

Departmental Affiliations

School of Medicine
Joint

Philip Jordan, PhD, studies how cells accurately pass on their DNA from one generation to the next and the diseases that are caused when this goes wrong.

Contact Info

615 N. Wolfe Street, Room E8626
Baltimore
Maryland
21205
US        
+1 (410) 955 2926

Research Interests

Genome maintenance; Meiosis; Embryonic stem cells; DNA recombination; Chromosome segregation; Structural Maintenance of Chromosomes (SMC); SMC5/6; Cohesin, Condensin; Synaptonemal complex; Polo-like kinase (PLK); Aurora kinase (AURK)
Experiences & Accomplishments
Education
PhD
University of Edinburgh
2006
BS
Flinders University of South Australia
2001
Overview
Research in the Jordan laboratory focuses on understanding the molecular mechanisms regulating DNA repair, chromosome segregation and cell cycle progression. Their lab studies the importance of Structural Maintenance of Chromosomes (SMC) complexes and cell cycle kinases, particularly Polo-like (PLK) kinases and Aurora kinases. The Jordan lab uuse mouse as a model organism to study consequences of gene mutation and chromosome missegregation, which give rise to physical and mental developmental defects, infertility and cancer predisposition. They also use mouse and human pluripotent stem cells to help define the function of these proteins within essential molecular pathways of the cell. Current research from the Jordan laboratory encompasses the following: 1) Gametogenesis (spermatogenesis and oogenesis) 2) Pluripotent stem cell preservation, proliferation, and differentiation 3) Neurodevelopment ______________________________________________________________________________ CURRENT LAB MEMBERS: Philip Jordan - Principle Investigator Marina Pryzhkova - Assistant Scientist Michelle Xu - PhD student Marnie Skinner - PhD student Carter Simington - ScM Masters student Kerstin Baran - ScM Masters student GRADUATED STUDENTS: Ayobami Ward - ScM Masters student - 2015 Himaja Gaddipati - ScM Masters student - 2015 Miebaka Jamabo - ScM Masters student - 2016 Zach Perdun - ScM Masters student - 2017 Maria Laura Reategui - ScM Masters student - 2018 Xueqi Zhao - ScM Masters student - 2018 Grace Hwang - PhD student - 2018 Jessica Hopkins - PhD student - 2018 Yujiao Zhang - ScM Masters student - 2019 Nathaniel Rogers - ScM Masters student - 2019 Stephen Wellard - PhD student - 2020 Tara Biser - PhD student - 2020 Alisa Boyko - PhD student - 2020 Chris Shults - ScM Masters student - 2020 Maggie Li - ScM Masters student - 2020 ______________________________________________________________________________
Honors & Awards
2021: R01 NIH Research Grant, NIGMS 2019: R03 NIH Research Grant, NINDS 2018: Johns Hopkins University Catalyst Award 2017: KY Cha Award in Stem Cell Technology, ASRM 2017: Johns Hopkins Discovery Award 2017: R21 NIH Research Grant, ORIP 2016: R01 NIH Research Grant, NIGMS 2015: Johns Hopkins University Discovery Award 2014: Ho-Ching Yang Memorial Faculty Fellowship in Cancer Prevention 2013: R00 NIH Pathway to Independence Award, NICHD 2011: K99 NIH Pathway to Independence Award, NICHD 2010: US-UK Fulbright Distinguished Scholar Award, US-UK Fulbright Commission 2006: Federation of European Biochemical Societies Research Award 2005: Society for General Microbiology President’s Research Award and post-funding prize 2005: European Unions’ ERASMUS Student Mobility Award 2004: British Council - Austrian Academic Research Collaboration Award 2002: Darwin Trust International PhD Scholarship, University of Edinburgh, Scotland ______________________________________________________________________________
Select Publications
Selected example publications from the Jordan lab
  • Wellard SR, Zhang Y, Shults C, Zhao X, McKay M, Murray SA, Jordan PW (2021) Overlapping Roles for PLK1 and Aurora A kinases during Meiotic Centrosome Biogenesis in Mouse Spermatocytes. EMBO Rep. e51023.
  • Pryzhkova MP, Xu M and Jordan PW. (2020) Adaptation of the AID system for stem cell and transgenic mouse research. Stem Cell Research. (49): 102078.
  • Alisa Atkins, Michelle J. Xu, Maggie Li, Nathaniel P. Rogers, Marina V. Pryzhkova, Philip W. Jordan (2020) SMC5/6 is required for replication fork stability and faithful chromosome segregation during neurogenesis. eLife. e61171.
  • Wellard S, Schindler K and Jordan PW (2020) Aurora B and Aurora C kinases regulate synaptonemal complex disassembly in male mice and humans. J. Cell Sci. 133: jcs248831.
  • Little T and Jordan PW. (2020) PLK1 is required for normal chromosome compaction and microtubule organization in mouse oocytes. Molecular Biology of the Cell. (31), 1206–1217.
Projects
Functions of the SMC5/6 complex
Polo-like kinases
Cohesin complex
Aurora kinases