G. Caleb Alexander, MD, MS, is a practicing internist and epidemiologist focused on maximizing the use, safety, and effectiveness of prescription medicines.
prescription drugs; drug utilization; drug safety; drug effectiveness; patient-provider communication; pharmacoepidemiology; regulatory policy; Food and Drug Administration
Experiences & Accomplishments
Dr. Alexander is a Professor of Epidemiology and Medicine at the Johns Hopkins Bloomberg School of Public Health, where he serves as founding co-Director of the Center for Drug Safety and Effectiveness and Principal Investigator of the Johns Hopkins-FDA Center of Excellence in Regulatory Science and Innovation (JH-CERSI). He is a practicing general internist and pharmacoepidemiologist and is internationally recognized for his research examining prescription drug utilization, safety and effectiveness. The author of over 375 scientific articles and book chapters, many of which have focused on the epidemiology of the opioid epidemic, he has published regularly in leading scientific journals and testified in front of expert bodies including the U.S. House of Representatives and U.S. Senate. Dr. Alexander also serves on several editorial and advisory boards and is a frequent speaker on pharmaceutical utilization and policy. He received his B.A. cum laude from the University of Pennsylvania, an MD from Case Western Reserve University, and a Master of Science from the University of Chicago.
Research Interests: prescription drugs; drug utilization; drug safety; drug effectiveness; pharmacoepidemiology; pharmaceutical policy
Honors & Awards
1993 Cum Laude, University of Pennsylvania
1997 Alpha Omega Alpha, Case Western Reserve University
2011 Elected Fellow of the American College of Physicians (FACP)
2001 Edward W. Holmes Resident Research Award, University of Pennsylvania
2006-2009 Robert Wood Johnson Foundation Faculty Scholar
2007 Research Finalist, International Society for Pharmacoeconomics and Outcomes Research, Annual Meeting
2008 Outstanding Physician Scientist Award, Central Society for Clinical Research
2008 Career development award, Central Society for Clinical Research
2008 Department of Medicine Research Award (awarded to trainee for mentored research; also received by mentored trainees in 2009 and 2010)
2009 Pritzker School of Medicine Sigma Xi Award for Impact on Science (awarded to trainee for mentored research)
Select Scientific Publications (of over 375 total)
Alexander GC, Knopman DS, Emerson SS, Ovbiagele B, Kryscio RJ, Perlmutter JS, Kesselheim AS. Revisiting FDA Approval of Aducanumab. N Engl J Med. 2021 Aug 26;385(9):769-771. doi: 10.1056/NEJMp2110468. Epub 2021 Jul 28. PMID: 34320282.
Andersen KM, Mehta HB, Palamuttam N, Ford D, Garibaldi BT, Auwaerter PG, Segal J, Alexander GC. Association Between Chronic Use of Immunosuppresive Drugs and Clinical Outcomes From Coronavirus Disease 2019 (COVID-19) Hospitalization: A Retrospective Cohort Study in a Large US Health System. Clin Infect Dis. 2021 Jan 7:ciaa1488. doi: 10.1093/cid/ciaa1488. Epub ahead of print. PMID: 33410884; PMCID: PMC7953980.
Qato DM, Wilder J, Schumm P, Gillet V, Orr A, Alexander GC. Use of Prescription and Over-the-counter Medications and Dietary Supplements Among Older Adults in the United States: 2005-2006 to 2010-2011. JAMA Internal Medicine. 2016;176:473-82.
Alexander GC, Frattaroli S, Gielen AC, eds. The Opioid Epidemic: From Evidence to Impact. Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland: 2017.
Kolodny A, Courtwright DT, Hwang CS, Kreiner P, Eadie JL, Clark TW, Alexander GC. The Prescription Drug Opioid and Heroin Crisis: A Public Health Approach to an Epidemic of Addiction. Annual Review of Public Health. 2015;36:559-574.