Xiumei Hong, MD, PhD, investigates lifestyle, genetic variants, epigenetic alterations, metabolomic profiles and their interactions associated with complex child diseases.
Genomics; Epigenomics; Metabolomics; Multi-omics; DNA Methylation; Gene-Environment Interaction; Child Health; Food Allergy; Asthma; Preterm Birth
Experiences & Accomplishments
Anhui Medical University
University of Science & Technology of China
Dr Hong is a molecular epidemiologist with extensive experience in epidemiology and molecular genetics. Her research interest is to integrate “multi-omics” and big data with large-scale epidemiologic studies to systematically investigate the environmental exposure, lifestyle, genetic variants, epigenetic alterations, metabolomic profiles and their interactions associated with complex child diseases, especially prematurity, allergy and asthma. She also has vast experience in data management, data analyses and data integration. Over the past 5 years, She has served as a co-investigator for multiple large-scale population studies funded by the National Institute of Health and by Health Resources and Services Administration in diverse populations, and has collaborated with multi-disciplinary investigators within the U.S and abroad. She has authored and co-authored over 80 publications in peer-reviewed scientific journals, including prestigious journals such as JAMA, Nature Communication and the Journal of Allergy and Clinical Immunity.
Honors & Awards
2013 Best poster for Population, Family & Reproduction Health Research day 2017 Pilot study award, Hopkins Population Center 2019 Pilot study award, Hopkins Population Center 2020 Discovery award, Johns Hopkins
Selected publications from the last five years (selected from over 80 peer-reviewed publications)
- Hong X*, Liang L, Sun Q, Keet CA, Tsai HJ, Ji Y, Wang G, Ji H, Clish C, Pearson C, Wang Y, Wood RA, Hu FB, Wang X. Maternal triacylglycerol signature and risk of food allergy in offspring. J Allergy Clin Immunol. 2019 Sep;144(3):729-737.
- Li J, Hong X, Mesiano S, Muglia LJ, Wang X, Snyder M, Stevenson DK, Shaw GM. Natural selection has differentiated the progesterone recetpor among human populations. Am J Hum Genet. 2018 Jul 5; 103(1): 45-57.
- Hong X, Hao K, Ji H, Peng S, Sherwood B, Narzo AD, Tsai HJ, Liu X, Burd I, Wang G, Ji Y, Caruso D, Mao G, Bartell TR, Zhang Z, Pearson C, Heffner L, Cerda S, Beaty TH, Fallin MD, Aviva Lee-Parritz A, Zuckerman B, Weeks DE, Wang X. Genome-wide approach identified a novel gene-maternal pre-pregnancy BMI interaction on preterm birth. Nat Commun, 2017, June 9;8:15608
- Hong X, Ladd-Acosta C, Hao K, Sherwood B, Ji H, Keet CA, Kumar R, Caruso D, Liu X, Wang G, Chen Z, Ji Y, Mao G, Walker SO, Bartell TR, Ji Z, Sun Y, Tsai HJ, Pongracic JA, Weeks DE, Wang X. Epigenome-wide association study links site-specific DNA methylation changes with cow's milk allergy. J Allergy Clin Immunol. 2016 Sep; 138(3):908-911.e9.
- Hong X, Hao K, Ladd-Acosta C, Hansen KD, Tsai HJ, Liu X, Xu X, Thornton TA, Caruso D, Keet CA, Sun Y, Wang G, Luo W, Kumar R, Fuleihan R, Singh AM, Kim JS, Story RE, Gupta RS, Gao P, Chen Z, Walker S, Bartell TR, Beaty TH, Fallin MD, Schleimer R, Holt PG, Nadeau KC, Wood RA, Pongracic JA, Weeks DE, Wang X. Genome-wide Association Study of Food Allergy Identifies Peanut Allergy-Specific Susceptibility Loci and Evidence of Epigenetic Mediation in U.S. Children of European Ancestry. Nat Commun. 2015 Feb 24;6:6304.
Early Life Determinants of Obesity in U.S. Urban Low Income Minority Birth Cohort
A Prospective Birth Cohort Study on Pre- and Peri-natal Determinants of Autism Spectrum Disorders and Developmental Disabilities
Prenatal Multi-Level Stressors and Alterations in Maternal and Fetal Epigenomes
Maternal Stress and Preterm Birth: Role of Genome and Epigenome
Preterm Birth, Maternal and Cord Blood Metabolome, and Child Metabolic Risk
Inter-generational Link of Cardio-Metabolic Risk: Integrate Multi-OMICs with Birth Cohort
Maternal and Cord Blood Metabolome, Infant Feeding, and Development of Food Allergy in a Prospective Birth Cohort