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Ann-Margret
Ervin
,
PhD

Associate Scientist

Ann-Margret Ervin, PhD ’06, MPH, conducts methodological research on the design, conduct, and reviews of ocular disease clinical trials and therapeutic interventions.

Contact Info

615 N. Wolfe Street, Room E6146
Baltimore
Maryland
21205
US        

Research Interests

epidemiology; clinical trials; clinical trials methodology; visual impairment; eye disease; ophthalmology; bioethics; research ethics; systematic reviews and meta-analysis
Experiences & Accomplishments
Education
PhD
Johns Hopkins University
2006
MPH
Emory University
1995
Overview
Dr. Ervin's research interests focus on the design and conduct of randomized clinical trials of interventions to treat and prevent ocular disease and visual impairment. Dr. Ervin has contributed to numerous studies of the causes, prevention, diagnosis or treatment of disorders of the eye and visual system including age-related macular degeneration, refractive error, low vision, cataract, and diabetic retinopathy.  She is currently the Co-Principal Investigator of the Data Coordinating Center for a multicenter observational study of Stargardt Disease and for a clinical trial of lutein and zeaxanthin for ocular and oculocutaneous albinism with colleagues at the Wilmer Eye Institute.   Dr. Ervin also conducts novel research on the ethical implications of US federal regulations for institutional review boards (IRBs). Dr. Ervin is keenly interested in the impact of federal regulations on the design and conduct of multicenter clinical trials, specifically the advantages and disadvantages of alternate IRB review models for streamlining ethical review in the multicenter setting. She is currently the Co-Principal Investigator of an NIH-funded project to establish priorities for the principles and practices of central IRBs in the multicenter study setting. The project investigators will propose guidance for institutions and investigators involved in central IRB review of a multicenter clinical trial and for sponsors recommending use of central IRBs for multicenter trials.
Honors & Awards
Clinical Trials Training Program in Vision Research Fellowship, National Eye Institute, Johns Hopkins Bloomberg School of Public Health Dean’s Scholar Academic Scholarship, Emory University
Select Publications
Selected publications since 2015.
  • Ervin AM, Taylor HA, Ehrhardt S, Meinert CL. Why public comments matter: An analysis of the NIH draft policy on single IRB review of multicenter studies. Academic Medicine 2018 August; 93: 1157 - 1161.
  • Ervin AM, Law A, Pucker AD. Punctal occlusion for dry eye syndrome: Summary of a Cochrane systematic review. British Journal of Ophthalmology 2018 October E-pub ahead of print. doi:10.1136/bjophthalmol-2018-313267. Ervin AM, Law A, Pucker AD. Punctal occlusion for dry eye syndrome. Cochrane Database of Systematic Reviews 2017 Issue 6 Art. No.: CD006775. DOI: 10.1002/14651858.CD006775.pub3.
  • Ervin AM, Taylor HA, Ehrhardt S. NIH policy on single IRB review: a new era in ethical review of multicenter studies. New England Journal of Medicine, 2016 December 15; 375 (24): 2315 – 2317.
  • Ervin AM, Taylor HA, Meinert CL, Ehrhardt S. Evidence gaps and ethical review of multicenter studies. Science, 2015 November 6; 350 (6261): 632-3.
  • Ervin AM, Mkocha H, Munox BE, Dreger K, Dize L, Gaydos CA, West SK. Surveillance and Azithromycin Treatment for Newcomers and Travelers Evaluation (ASANTE) Trial: Design and Baseline Characteristics. Ophthalmic Epidemiology, 2016 November 7; 23 (6): 347–353. http://dx.doi.org/10.1080/09286586.2016.1238947
Projects
The Natural History of the Progression of Atrophy Secondary to Stargardt Disease (ProgStar) Studies