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Associate Professor
Qian-Li Xue

Departmental Affiliations

School of Medicine
Epidemiology of Aging

Center & Institute Affiliations

Contact Info

2024 E. Monument Street, Suite 2-700

Research Interests

Epidemiology,Epidemiological design; latent variable; longitudinal data; measurement error; missing data; multivariate categorical data
Experiences & Accomplishments
My primary area of statistical expertise is the development and application of statistical methods for (i) handling truncation of information on underlying or unobservable outcomes (e.g., disability) as a result of screening, (ii) missing data including outcome (e.g. frailty) censoring by a competing risk (e.g. mortality), and (iii) trajectory analysis of multivariate outcomes. Other areas of methodologic research interests include multivariate, latent variable models.
In Women's Health and Aging Studies, I have closely collaborated with scientific investigators on the design and analysis of longitudinal data relating biomarkers of inflammation, hormonal dysregulation, and micronutrient deficiencies to the development and progression of frailty and disability, as well as characterizing the natural history of change in cognitive and physical function over time.
Honors & Awards
2000 Student Paper Award from the International Biometrics Society Eastern North American Region
2007 Travel Award, Conference on Biomarkers of Aging, American Federation of Aging Research
2010-2011 Nathan Shock Scholar, the Nathan W. and Margaret T. Shock Aging Research Foundation
2020 - Fellow, Gerontological Society of America
Select Publications
Selected publications from the last five years
  • Xue QL, Bandeen-Roche K, Tian J, Kasper JD, Fried LP. Progression of Physical Frailty and the Risk of All-Cause Mortality: Is There a Point of No Return? J Am Geriatr Soc. 2020 Dec 24. doi: 10.1111/jgs.16976. Online ahead of print. PMID: 33368158
  • Ge N, Westbrook R, Langdon J, Yang H, Marx R, Abadir P, Xue QL, Walston JD. Impaired Stress Response System in Aging and Chronic Inflammation: Implications for Resiliency Research. Exp Gerontol. 2020 Oct 24;142:111136. doi: 10.1016/j.exger.2020.111136. Online ahead of print. PMID: 33164891
  • Xue QL. Frailty as an integrative marker of physiological vulnerability in the era of COVID-19. BMC Med. 2020 Oct 23;18(1):333. doi: 10.1186/s12916-020-01809-1. PMID: 33092582
  • Xue QL, Buta B, Ma LN, Ge ML, Carlson MC. Integrating Frailty and Cognitive Phenotypes: Why, How, Now What? Curr Geriatr Rep. 2019 Jun;8(2):97-106. Epub 2019 Apr 24. PMID: 31815092
  • Xue QL, Tian J, Walston JD, Chaves PHM, Newman AB, Bandeen-Roche K. Discrepancy in Frailty Identification: Move beyond Predictive Validity. J Gerontol A Biol Sci Med Sci. 2019 Feb 21. pii: glz052. doi: 10.1093/gerona/glz052. [Epub ahead of print] PMID: 30789645
Clinical Significance of Short-term Change and Variability of Grip Strength
Frailty Assessment: Matching Simplification Efforts to Clinical Aims
Physical Frailty and Cognitive Impairment: Intersection, Measurement & Etiologies