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Jane
M.
Carlton
,
PhD

Visiting Professor

Contact Info

Research Interests

genomics; systems biology; malaria; Plasmodium; Anopheles; India; infectious diseases; Trichomonas

Experiences & Accomplishments
Education
PhD
University of Edinburgh
1995
BS
University of Edinburgh
1990
Overview

Dr Jane Carlton is Director of the Malaria Research Institute at the Johns Hopkins Bloomberg School of Public Health. She is passionate about genomics and its power to transform the study of important global health diseases such as malaria which cause illness and death among disadvantaged people in low-income countries. Her research involves using comparative genomics – literally comparing genomes -- to probe the biology and evolution of the malaria parasite and its mosquito vector, and to find better ways for malaria surveillance, treatment, and control. For close to 20 years she has worked in India most recently as Director of an NIH International Center of Excellence for Malaria Research based at six Indian institutions and with field sites in four different states. A more recent focus of the lab has been to use integrative genetics to study high-dimensional  multi-omics datasets from clinical samples in Ethiopia to develop a greater understanding of human host-Plasmodium parasite interactions. Other studies include comparative genomics of trichomonads, including the sexually transmitted parasite Trichomonas vaginalis and related species found in birds, pets, and livestock. 

Honors & Awards

1991    Royal Society of Great Britain Travel Award; William Dickson Travel Award

1993    Young Investigator Award, Scottish Universities Molecular Parasitology Group Summer Meeting

2004    Martin D. Rodbell Award, The Institute for Genomic Research, Maryland, USA

2005    Essential Science Indicator top 1% award for Plasmodium yoelii yoelii genome paper citations

2007    NYU School of Medicine Dean’s Honors 2007

2009    Thomson Reuters most cited papers in Microbiology published during last 2 years

2010    NYU School of Medicine Dean’s Honors 2010

2010    American Society of Parasitologists’ Stoll-Stunkard Memorial Award 

2012    Elected Fellow, American Association for the Advancement of Science

2018    Julius Silver, Roslyn S. Silver, and Enid Silver Winslow Professorship,  New York University

Select Publications

Selected publications.

  • Carlton JM, Angiuoli SV, Suh BB, Kooij TW, Pertea M, Silva JC, Ermolaeva MD, Allen JE, Selengut JD, Koo HL, Peterson JD, Pop M, Kosack DS, Shumway MF, Bidwell SL, Shallom SJ, van Aken SE, Riedmuller SB, Feldblyum TV, Cho JK, Quackenbush J,  Sedegah M, Shoaibi A, Cummings LM, Florens L, Yates JR, Raine JD, Sinden RE, Harris MA, Cunningham DA, Preiser PR, Bergman LW, Vaidya AB, van Lin LH, Janse CJ, Waters AP, Smith HO, White OR, Salzberg SL, Venter JC, Fraser CM, Hoffman SL, Gardner MJ, Carucci DJ.Genome sequence and comparative analysis of the model rodent malaria parasite Plasmodium yoelii yoelii. Nature. 2002 Oct 3;419(6906):512-9. 

  • Carlton JM, Hirt RP, Silva JC, Delcher AL, Schatz M, Zhao Q, Wortman JR, Bidwell SL, Alsmark UC, Besteiro S, Sicheritz-Ponten T, Noel CJ, Dacks JB, Foster PG, Simillion C, Van de Peer Y, Miranda-Saavedra D, Barton GJ, Westrop GD, Muller S, Dessi D, Fiori PL, Ren Q, Paulsen I, Zhang H, Bastida-Corcuera FD, Simoes-Barbosa A, Brown MT, Hayes RD, Mukherjee M, Okumura CY, Schneider R, Smith AJ, Vanacova S, Villalvazo M, Haas BJ, Pertea M, Feldblyum TV, Utterback TR, Shu CL, Osoegawa K, de Jong PJ, Hrdy I, Horvathova L, Zubacova Z, Dolezal P, Malik SB, Logsdon JM Jr, Henze K, Gupta A, Wang CC, Dunne RL, Upcroft JA, Upcroft P, White O, Salzberg SL, Tang P, Chiu CH, Lee YS, Embley TM, Coombs GH, Mottram JC, Tachezy J, Fraser-Liggett CM, Johnson PJ. Draft genome sequence of the sexually transmitted pathogen Trichomonas vaginalis. Science. 2007 Jan 12;315(5809):207-12. 

  • Carlton JM, Adams JH, Silva JC, Bidwell SL, Lorenzi H, Caler E, Crabtree J, Angiuoli SV, Merino EF, Amedeo P, Cheng Q, Coulson RM, Crabb BS, Del Portillo HA, Essien K, Feldblyum TV, Fernandez-Becerra C, Gilson PR, Gueye AH, Guo X, Kang'a S, Kooij TW, Korsinczky M, Meyer EV, Nene V, Paulsen I, White O, Ralph SA, Ren Q, Sargeant TJ, Salzberg SL, Stoeckert CJ, Sullivan SA, Yamamoto MM, Hoffman SL, Wortman JR, Gardner MJ, Galinski MR, Barnwell JW, Fraser-Liggett CM. Comparative genomics of the neglected human malaria parasite Plasmodium vivax. Nature. 2008 Oct 9;455(7214):757-63.

  • Hupalo DN, Luo Z, Melnikov A, Sutton PL, Rogov P, Escalante A, Vallejo AF, Herrera S, Arévalo-Herrera M, Fan Q, Wang Y, Cui L, Lucas CM, Durand S, Sanchez JF, Baldeviano GC, Lescano AG, Laman M, Barnadas C, Barry A, Mueller I, Kazura JW, Eapen A, Kanagaraj D, Valecha N, Ferreira MU, Roobsoong W, Nguitragool W, Sattabonkot J, Gamboa D, Kosek M, Vinetz JM, González-Cerón L, Birren BW, Neafsey DE, Carlton JM. Population genomics studies identify signatures of global dispersal and drug resistance in Plasmodium vivax. Nat Genet. 2016 Aug;48(8):953-8

  • Carlton JM, Sahu PK, Wassmer SC, Mohanty S, Kessler A, Eapen A, Tomko SS, Walton C, Joshi PL, Das D, Albert S, Peter BK, Pradhan MM, Dash AP, Das A. The Impact, Emerging Needs, and New Research Questions Arising from 12 Years of the Center for the Study of Complex Malaria in India. Am J Trop Med Hyg. 2022 Oct 11;107(4_Suppl):90-96. doi: 10.4269/ajtmh.21-1277. PMID: 36228922. 

Projects
Center for the Study of Complex Malaria in India
A cluster randomized trial to assess the effectiveness of malaria camps as part of the DAMaN program in Odisha, India
VectorCAM: Digital Innovations to Advance Entomological Surveillance
Genomic surveillance of malaria parasites in travelers returning to the USA
High quality reference genomes and transcriptomes of circulating drug resistant Plasmodium vivax from key endemic regions
A social science approach to tailoring strategies for malaria control and elimination in Meghalaya, Ind
Characterization of the Pseudocyst Stage of the Sexually Transmitted Parasite Trichomonas vaginalis and Persistent Infections in Women
Delivering FAIR Datasets for the Neglected Parasite Trichomonas vaginalis and Studies in Comparative Genomics.
Tool development for studying COVID-19/malaria co-infections in India
A Pilot Project to Discover Protists in the Pests and Pets of New York City