Center & Institute Affiliations
Sean Prigge, PhD, is a structural biologist and parasitologist who studies essential nutrients and metabolic pathways in malaria parasites.
Experiences & Accomplishments
- Russell P Swift, Krithika Rajaram, Hans B Liu, and Sean T Prigge, Dephospho-CoA kinase, a nuclear-encoded apicoplast protein, remains active and essential after Plasmodium falciparum apicoplast disruption. EMBO J, 40, e107247 (2021).
- Russell P Swift, Krithika Rajaram, Cyrianne Keutcha, Hans B Liu, Bobby Kwan, Amanda Dziedzic, Anne E Jedlicka, and Sean T Prigge. The NTP generating activity of pyruvate kinase II is critical for apicoplast maintenance in Plasmodium falciparum. Elife, 9, e50807 (2020).
- Russell P Swift, Krithika Rajaram, Hans B Liu, Amanda Dziedzic, Anne E Jedlicka, Aleah D Roberts, Krista A Matthews, Hugo Jhun, Namandje N Bumpus, Shivendra G Tewari, Anders Wallqvist, and Sean T Prigge. A mevalonate bypass system facilitates elucidation of plastid biology in malaria parasites. PLoS Pathog, 16, e1008316 (2020).
- Aleah D Roberts, Sethu C Nair, Alfredo J Guerra, and Sean T Prigge. Development of a conditional localization approach to control secretory protein trafficking in malaria parasites. Traffic, 20, 571-582 (2019).
- Teegan A Dellibovi-Ragheb, Hugo Jhun, Christopher D Goodman, Maroya S Walters, Daniel R T Ragheb, Krista A Matthews, Krithika Rajaram, Satish Mishra, Geoffrey I McFadden, Photini Sinnis, and Sean T Prigge. Host biotin is required for liver stage development in malaria parasites. Proc Natl Acad Sci U S A, 115, E2604-E2613 (2018).