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Methods and Applications of Cohort Studies

Summer Institute
Academic Year
2024 - 2025
Instruction Method
Synchronous Online
Start Date
Monday, June 24, 2024
End Date
Friday, June 28, 2024
Class Time(s)
M, Tu, W, Th, F, 8:30am - 12:00pm
Auditors Allowed
Available to Undergraduate
Grading Restriction
Letter Grade or Pass/Fail
Contact Name
Frequency Schedule
Every Year

Intermediate-level courses in both epidemiology and biostatistics and some familiarity with data analysis software packages.

Cohort studies are central to understanding the natural history of disease and making inferences about risk factors associations with disease. The course will cover the principles of rigorous cohort study design, analysis and critical evaluation. Mastery of the material will be enhanced by examples from leading cohort studies and laboratory exercises analyzing large cohort datasets.
Teaches general methods and applies to cohort studies of chronic and infectious disease, including HIV, COVID-19, cardiovascular disease, and cancer. Includes topics: definition, design, and basic characteristics of cohort studies; conceptual underpinnings of survival analysis; methods for the analysis of survival data including modeling and testing of relative hazards (Cox regression), and relative incidence (Poisson and negative binomial regression); methods to nest case-control and case-cohort designs in cohort studies; risk prediction (AUC and NRI) and a discussion of key challenges in the conduct and analysis of modern cohort studies.
Learning Objectives
Upon successfully completing this course, students will be able to:
  1. Describe the principles for the design and conduct of cohort studies
  2. Estimate and compare incidence rates, and times-to-event via relative hazards and relative times
  3. Apply analytic methods to data from major cohort studies
  4. Appreciate the role of cohort studies for the characterization of natural history of diseases; for understanding etiology, evaluation of interventions and for guiding public policy
Methods of Assessment
This course is evaluated as follows:
  • 10% Participation
  • 90% Quizzes
Special Comments

Students who have successfully completed 340.728: Methods and Applications of Cohort Studies should not enroll in this course.

Course will be taught online via Zoom, on the dates and times the course is scheduled.