187.645.81
Toxicology 21: Scientific Applications
Location
Internet
Term
3rd Term
Department
Environmental Health and Engineering
Credit(s)
3
Academic Year
2024 - 2025
Instruction Method
Asynchronous Online
Auditors Allowed
Yes, with instructor consent
Available to Undergraduate
No
Grading Restriction
Letter Grade or Pass/Fail
Course Instructor(s)
Contact Name
Frequency Schedule
Every Year
Resources
Prerequisite
187.632 Molecular toxicology; Background in molecular and cell biology recommended
Familiarizes students with the novel concepts being used to revamp regulatory toxicology in response to a breakthrough National Research Council Report “Toxicity Testing in the 21st Century: A Vision and a Strategy.” Presents the latest developments in the toxicology field: moving away from animal testing toward human relevant, high content, high throughput integrative testing strategies. Active programs from EPA, NIH and the scientific community work-wide illustrate the dynamics of safety sciences.
Learning Objectives
Upon successfully completing this course, students will be able to:
- Debate and criticize the shortcomings of the current approach to hazard assessment
- Evaluate the technologies entering the regulatory arena
- Explain the challenges of toxicology 21st century to change the paradigm in toxicology
- Explain mechanism of toxicity and toxicokinetics as the basis for testing strategies
- Describe novel types of data and bioinformatics entering regulatory evaluations
- Implement Tox21 (PubChem, Data Visualization and integration suites) and ToxCast (iCSS Dashboard) interactive web applications to mine and assess Tox21 and ToxCast high-throughput chemical screening data