140.652.01
Methods in Biostatistics II

Location
East Baltimore
Term
2nd Term
Department
Biostatistics
Credit(s)
4
Academic Year
2024 - 2025
Instruction Method
In-person
Class Time(s)
Tu, Th, 10:30 - 11:50am
Lab Times
Tuesday, 3:30 - 4:20pm (01)
Wednesday, 3:30 - 4:20pm (02)
Auditors Allowed
Yes, with instructor consent
Available to Undergraduate
Yes
Grading Restriction
Letter Grade or Pass/Fail
Course Instructor(s)
Ravi Varadhan
Contact Name
Ravi Varadhan
Frequency Schedule
Every Year
Prerequisite

140.651

Description
Continues studying hypothesis testing and estimation concepts in the second part of the course. Includes the following topics: (1)power of tests, (2) P-value and its properties; (3) Binomial proportion; Wald test; Score test; exact test; (4) Two-sample binomial; odds ratio (OR), relative risk (RR),risk difference (RD); (5) Hypergeometric distribution and Fisher’s exact test; (6)Confounding; stratification; Mantel-Haenszel estimator; (7) More on OR, RR, RD; Simpson’s paradox; collapsibility; (8) Case-control; Matched case-control; McNemar’s test; (9) Goodness of fit tests and Chi-squared test for contingency tables; (10)Nonparametric statistics; (11) ANOVA: one-way and two-way; (12) Survival analysis, Kaplan-Meier estimation
Learning Objectives
Upon successfully completing this course, students will be able to:
  1. Discuss core applied statistical concepts and methods
  2. Discuss the display and communication of statistical data
  3. Describe the distinctions between the fundamental paradigms underlying statistical methodology
  4. List the basics of maximum likelihood
  5. List the basics of frequentist methods: hypothesis testing, confidence intervals
  6. Discuss the creation and interpretation of P values
  7. Describe estimation, testing and interpretation for single group summaries such as means, medians, variances, correlations and rates
  8. Describe estimation, testing and interpretation for two group comparisons such as odds ratios, relative risks and risk differences
  9. Describe the basic concepts of ANOVA
  10. Describe the basic ideas of nonparametric methods
  11. Describe the basic concepts of Kaplan-Meier estimation
Methods of Assessment
This course is evaluated as follows:
  • 40% Homework
  • 20% Midterm
  • 10% Final Project
  • 30% Final Exam
Instructor Consent
No consent required
Special Comments

Students will choose only one of the two lab times.