Skip to main content

Nucleic Acid Chemistry

3rd Term
Biochemistry and Molecular Biology
Academic Year
2023 - 2024
Instruction Method
Synchronous Online
Class Time(s)
M, W, 3:30 - 4:50pm
Auditors Allowed
Yes, with instructor consent
Available to Undergraduate
Grading Restriction
Letter Grade or Pass/Fail
Course Instructor(s)
Contact Name
Frequency Schedule
Every Year

Organic Chemistry and Biochemistry and/or Molecular Biology

Discusses nucleic acid structure, and also describes techniques for manipulating and analyzing nucleic acids, including gel electrophoresis, PCR, and DNA sequencing. Reviews methods used to synthesize nucleosides, nucleotides and oligonucleotides, and chemical reactions that lead to modifications of nucleic acids. Covers topics including DNA-drug interactions, antisense and antigene oligonucleotides, ribozymes and deoxyribozymes, DNA cages, DNA origami, DNA nanostructures, and DNA nanodevices.
Learning Objectives
Upon successfully completing this course, students will be able to:
  1. Design schemes to synthesize nucleosides, oligonucleotides and oligonucleotide conjugates
  2. Predict the products of reactions between nucleic acids and various chemical agents, ionizing and ultraviolet radiation
  3. Describe the design and function of antisense and antigene oligonucleotides, siRNAs, and nucleic acid aptamers
  4. Describe how ribozymes and DNAzymes catalyze chemical reactions
  5. Describe the design, synthesis and function of nucleic acid nanostructures and machines
Methods of Assessment
This course is evaluated as follows:
  • 50% Midterm
  • 50% Final Exam
Special Comments

This is the virtual/online section of a course also held onsite. You are responsible for the modality in which you register.