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Toxicology 21: Scientific Applications

3rd Term
Environmental Health and Engineering
Academic Year
2017 - 2018
Instruction Method
Auditors Allowed
Yes, with instructor consent
Available to Undergraduate
Grading Restriction
Letter Grade or Pass/Fail
Course Instructor(s)
Contact Name
Frequency Schedule
Every Year

187.632 Molecular toxicology; Background in molecular and cell biology recommended

Familiarizes students with the novel concepts being used to revamp regulatory toxicology in response to a breakthrough National Research Council Report “Toxicity Testing in the 21st Century: A Vision and a Strategy.” Presents the latest developments in the toxicology field: moving away from animal testing toward human relevant, high content, high throughput integrative testing strategies. Active programs from EPA, NIH and the scientific community work-wide illustrate the dynamics of safety sciences.
Learning Objectives
Upon successfully completing this course, students will be able to:
  1. Debate and criticize the shortcomings of the current approach to hazard assessment
  2. Evaluate the technologies entering the regulatory arena
  3. Explain the challenges of toxicology 21st century to change the paradigm in toxicology
  4. Explain mechanism of toxicity and toxicokinetics as the basis for testing strategies
  5. Describe novel types of data and bioinformatics entering regulatory evaluations
  6. Implement Tox21 (PubChem, Data Visualization and integration suites) and ToxCast (iCSS Dashboard) interactive web applications to mine and assess Tox21 and ToxCast high-throughput chemical screening data