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Joseph
Margolick
,
MD

Professor

Contact Info

615 N. Wolfe Street, Room E5153
Baltimore
Maryland
21205
US        

Research Interests

  • Human immunodeficiency virus
  • immune assessment
  • immune deficiency
  • T-cells
  • flow cytometry
  • cell sorting
  • pathogenesis of HIV
Experiences & Accomplishments
Education
MD
University of Southern California
1978
PhD
University of Southern California
1978
Overview

My training is in medicine, experimental pathology, and immunology. My research activities center on the cellular immunology and pathogenesis of infection with human immunodeficiency virus (HIV), and I also direct the flow cytometry core laboratory for the School of Hygiene and Public Health. Some specific research interests are:

 

Regulation of T Cell turnover and homeostasis in HIV infection. Effects of illicit drugs on immune function. Early events in HIV infection

Select Publications
  • Margolick, J.B., Muñoz, A., Donnenberg, A., Park, L.P., Galai, N., Giorgi, J.V., O'Gorman, M., Ferbas, J. and the Multicenter AIDS Cohort Study. Failure of T cell homeostasis preceding AIDS in HIV-1 infection. Nature Medicine 1:674-680, 1995.

  • Galai, N., Park, L.P., Wesch, J., Visscher, B., Riddler, S., Margolick, J.B. Effect of smoking on the clinical progression of HIV-1 infection. J, Acquir. Immune Defic. Syndr. Hum. Retrovirol. 14:451-458, 1997.

  • Gange, S.J., Muñoz, A., Chmiel, J.S., Donnenberg, A.D., Detels, R., Margolick, J.B. Identification of inflections in T-cell counts among HIV-1-infected individuals and relationship with progression to clinical AIDS. Proc. Nat. Acad. Sci. 95:10848-10853, 1998.

  • Shankarappa, R., Margolick, J.B., Gange, S.J., Rodrigo, A.G., Upchurch, D., Farzadegan, H., Gupta, P., Rinaldo, C.R., Learn, G.H., He, X.; Huang, X.L, Mullins, J.I. Consistent viral evolutionary changes associated with the progression of human immunodeficiency virus type 1 infection. J. Virol. 73:10489-10502, 1999.

  • Maas, J., Gange, S.J., Schuitemaker, H., Coutinho, R., van Leeuwen, R., Margolick, J.B. Strong association between failure of T cell homeostasis and the syncytium-inducing phenotype among HIV-1-infected men in the Amsterdam Cohort Study. AIDS 14:1155-1161, 2000.

Projects
SHIELD - The Study of HIV Infection in the Etiology of Lung Disease
HIV Prevention Trials Network: Immunology Core
ALIVE - AIDS Linked to the IntraVenous Experience