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The Design and Analysis of Cluster Randomized Trials

East Baltimore
4th Term
International Health
Academic Year
2022 - 2023
Instruction Method
Class Time(s)
Tuesday, 3:30 - 5:20pm
Auditors Allowed
Yes, with instructor consent
Available to Undergraduate
Grading Restriction
Letter Grade or Pass/Fail
Course Instructor(s)
Contact Name
Frequency Schedule
Every Year
Next Offered
2024 - 2025

Biostatistics 621, 622, 623, 624 or equivalent sequence.

Covers the major concepts and methods in the design and analysis of trial in which the unit of randomization is a group of participants. Focuses on design: discusses unmatched, matched, stepped wedge, and other approaches, with particular attention paid to randomization and sample size considerations. Presents a variety of methods for the analysis of these correlated-outcomes studies. Includes special aspects of infectious disease interventions.
Learning Objectives
Upon successfully completing this course, students will be able to:
  1. Identify when a cluster randomized trial may be preferable to an individually randomized trial
  2. Determine optimal design strategies for enabling estimation of efficacy and effectiveness parameters of interest
  3. Conduct and interpret statistical analyses appropriate to these designs
Methods of Assessment
This course is evaluated as follows:
  • 60% Weekly exercises
  • 40% Short project paper outlining a new trial with critical features and options discussed