The Design and Analysis of Cluster Randomized Trials
2022 - 2023
Tuesday, 3:30 - 5:20pm
Biostatistics 621, 622, 623, 624 or equivalent sequence.
Covers the major concepts and methods in the design and analysis of trial in which the unit of randomization is a group of participants. Focuses on design: discusses unmatched, matched, stepped wedge, and other approaches, with particular attention paid to randomization and sample size considerations. Presents a variety of methods for the analysis of these correlated-outcomes studies. Includes special aspects of infectious disease interventions.
Learning ObjectivesUpon successfully completing this course, students will be able to:
- Identify when a cluster randomized trial may be preferable to an individually randomized trial
- Determine optimal design strategies for enabling estimation of efficacy and effectiveness parameters of interest
- Conduct and interpret statistical analyses appropriate to these designs
Methods of Assessment
This course is evaluated as follows:
- 60% Weekly exercises
- 40% Short project paper outlining a new trial with critical features and options discussed