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Evidence-Based Toxicology

4th Term
Environmental Health and Engineering
Academic Year
2017 - 2018
Instruction Method
Auditors Allowed
Available to Undergraduate
Grading Restriction
Letter Grade or Pass/Fail
Course Instructor(s)
Contact Name
Frequency Schedule
Every Year

187.610 Public Health Toxicology

The National Toxicology Program, the Environmental Protection Agency and authorities worldwide, increasingly embrace the concepts of systematic reviews, meta-analysis, risk-of-bias, and quality assurance. Evidence-based toxicology (EBT) is a rapidly evolving discipline that represents a way to transparently and consistently evaluate scientific evidence, which can then be applied to address critical questions in toxicology. EBT is especially useful in the fields of regulatory toxicology and risk assessment, where numerous studies must be considered, weighed and integrated to support decision-making.
Provides students with fundamental knowledge about EBT approaches currently in use (or in development) that integrate and utilize diverse sources of data. These approaches include meta-analysis and systematic reviews, as used in evidence-based medicine. Introduces, explains and expands upon techniques such as risk of bias, QA/QC, good laboratory practice and validation, and the role that these tools and techniques play in assuring maximum confidence in evidence-based approaches.
Learning Objectives
Upon successfully completing this course, students will be able to:
  1. Discuss the advantages of evidence-based and bioinformatics approaches
  2. Describe the principles of systematic review and meta-analysis
  3. Explain quality assurance schemes in scientific work
  4. Explain the basis of validation processes
  5. Identify reasons for bias in scientific work
  6. Apply quality scoring to published studies