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Clinical Research and Epidemiology in Diabetes and Endocrinology

Leadership

Dr. Wendy Bennett

Wendy L. Bennett, MD, MPH

PROGRAM DIRECTOR
Associate Professor of Medicine
Research Director, General Internal Medicine

Dr. Todd T. Brown

Todd T. Brown, MD, PhD

PROGRAM DIRECTOR
Professor of Medicine and Epidemiology
Division of Endocrinology, Diabetes, and Metabolism

 

Dr. Sheela Magge

Sheela N. Magge, MD, MSCE

PROGRAM DIRECTOR
Professor of Pediatrics
Director, Division of Pediatric Endocrinology and Diabetes

Overview

Diabetes mellitus has reached epidemic proportions in the US and abroad. Other endocrinologic diseases, like hypothyroidism and osteoporosis are also extraordinarily common. Patient- and population-oriented researchers with expertise in these conditions are urgently required.

With this need in mind, in 2002, we established a training program at Johns Hopkins devoted to clinical and epidemiologic research in diabetes and endocrinology and funded by the National Institute of Diabetes, Digestive, and Kidney Diseases (NIDDK). 20 years later, it remains the only one of its kind in the US. The training program accepts three pre-doctoral students and two post-doctoral fellows per year and leads them to the MHS or PhD in clinical epidemiology or clinical investigation. Thus far, we have successfully trained 50 young scholars (25 pre-docs and 25 post-docs) who have produced over 128 peer-reviewed scientific papers and who hold research positions across the country.

Program Goals

The goals of our training program are:

  1. To recruit a diverse group of top-notch young trainees in endocrinology (post-docs) and epidemiology (pre-docs) from a national pool of talent attracted to Johns Hopkins.
  2. To enroll them in rigorous, thesis-bearing Masters’ and PhD programs in Epidemiology and Clinical Investigation in the Johns Hopkins Bloomberg School of Public Health.
  3. To expose them to a strong team-oriented, multi-disciplinary clinical and epidemiologic research culture in the Welch Center—the premier educational home for clinical research training at Johns Hopkins.
  4. To guide each trainee to an experienced, NIH-funded mentor who will take responsibility for the successful completion of a significant thesis project.

Program Strengths

The strengths of this program include:

  1. Strong existing diabetes and endocrine research collaborations between the Division of Endocrinology, Diabetes and Metabolism; Division of Pediatric Endocrinology; the Welch Center for Prevention, Epidemiology, and Clinical Research (Welch Center); the School of Public Health; and the School of Nursing
  2. Outstanding thesis-based degree programs in Epidemiology and Clinical Investigation at the School of Public Health
  3. Outstanding clinical expertise in diabetes and endocrine disorders
  4. Seasoned mentors experienced in grooming young scientists for academic careers, and
  5. High-caliber trainees wanting to pursue clinical and epidemiologic research careers related to diabetes and other endocrinology disorders.

Program Features

Program Options

Our pre-doctoral fellows are eligible for tuition support for their PhD program.  Our post-doctoral trainees have the opportunity of pursuing a MHS or PhD in the Graduate Training Program in Clinical Investigation.


Faculty Mentors

Rexford Ahima, MD, PhD Josef Coresh, MD, PhD, MHS Jenna Mammen, MD, PhD
G. Caleb Alexander, MD Jeanne M. Clark, MD, MPH Nestoras Mathioudakis, MD, MHS
Lawrence J. Appel, MD, MPH Gail Daumit, MD, MHS Erin Michos, MD, MHS
Sara Benjamin-Neelon, PhD Joel Gittelsohn, PhD Noel T. Mueller, PhD
Wendy Bennett, MD, MHS Kimberly Gudzune, MD, MHS Wendy Post, MD, MS
Todd T. Brown, MD, PhD Rita Kalyani, MD, MHS Jodi Segal, MD, MPH
Lisa A. Cooper, MD, MPH Sheela Magge, MD Elizabeth Selvin, PhD, MPH
Deidra Crews, MD, ScM Nisa Maruthur, MD, MHS Jessica Yeh, PhD


Areas Of Endocrine Research Training

Behavioral Science, Mental Health,
and Diabetes

Lawrence J. Appel, MD, MPH
Gail Daumit, MD, MHS
Kimberly Gudzune, MD, MHS
Disease Management
Lisa A. Cooper, MD, MPH
Rita Kalyani, MD, MHS
Human Physiology
Rexford Ahima, MD, PhD
Todd T. Brown, MD, PhD
Sheela Magge, MD
Nisa Maruthur, MD, MHS
Cardiovascular Disease
Josef Coresh, MD, PhD, MHS
Erin Michos, MD, MHS
Wendy Post, MD, MS
Elizabeth Selvin, PhD, MPH
Epidemiology
Josef Coresh, MD, PhD, MHS
Noel T. Mueller, PhD
Wendy Post, MD, MS
Elizabeth Selvin, PhD, MPH
Jessica Yeh, PhD
Nutrition
Lawrence J. Appel, MD, MPH
Joel Gittelsohn, PhD
Sara Benjamin-Neelon, PhD
Clinical Trials
Lawrence J. Appel, MD, MPH
Jeanne M. Clark, MD, MPH
Lisa A. Cooper, MD, MPH
Nisa Maruthur, MD, MHS
Nestoras Mathioudakis, MD, MHS
Endocrinology & Metabolism in Aging
Todd T. Brown, MD, PhD
Rita Kalyani, MD, MHS
Jenna Mammen, MD, PhD

Obesity
Lawrence J. Appel, MD, MPH
Jeanne M. Clark, MD, MPH
Joel Gittelsohn, PhD
Kimberly Gudzune, MD, MHS

Diabetes Prevention
Jeanne M. Clark, MD, MPH
Nisa Maruthur, MD, MHS
Nestoras Mathioudakis, MD, MHS
Health Disparities
Wendy Bennett, MD, MHS
Lisa A. Cooper, MD, MPH
Deidra Crews, MD, ScM
Pediatric Endocrinology
Sheela Magge, MD
Health Services & Comparative Effectiveness Research
Lawrence J. Appel, MD, MPH | Jeanne M. Clark, MD, MPH | Lisa A. Cooper, MD, MPH | 
Jodi Segal, MD, MPH | G. Caleb Alexander, MD | Wendy Bennett, MD, MHS


Research Data Resources

National Surveys

Name

Description

National Health and Nutrition Examination Survey (NHANES)

Personal interview, physical exam, lab tests, nutritional assessment
5,000 persons, all ages. Oversample young, old, minorities

National Health Interview Survey (NHIS)

Personal interview. ~ 40,000 household. Oversample blacks and Hispanics

Mortality Follow-ups for the NHANES and NHIS

NHANES III (baseline 1988 – 1994) has been linked to death through 2000. 9000-15,000 adults followed 8-12 years to mortality

Nation Hospital Discharge Survey (NHDS)

Hospital records, Computerized data sources from 500 hospitals with 300,000 discharges

Community-based Cohorts

Atherosclerotic Risk in Communities Study (ARIC)

Prospective cohort; 16,000 mid-aged adults from 4 U.S. communities
Details on cardiovascular disease risk factors

Multi-Ethnic Study of Atherosclerosis (MESA)

Prospective cohort from 6 sites with diverse and representative sample of ~ 7,000 men and women
Studies progression to clinical CVD

Jackson Heart Study (JHS)

Prosepective cohort of 5,200 African-American adults from Jackson, MS, USA

Studies risk factors for and progression of cardiovascular disease in African Americans


Clinical Trials

Name

Description

DPP Outcome Study (DPPOS)

Cohort after RCT; all DPP participants
Evaluate long-term effects of active DPP interventions on the development of diabetes, and microangiopathic and CVD outcomes

Look AHEAD

Largest study of weight loss ever conducted; 5,000 participants with diabetes
Hopkins is home to multiple federally supported ancillary studies including a) fatty liver; b) heavy metal exposure; c) environmental influences on weight and weight loss

Practice-Based Opportunities for Weight Reduction (POWER) Trial

Real world effectiveness trial designed to establish approaches to translate findings from major NIH lifestyle trials into clinical practice

 

Affiliated Research Centers And Departments

For additional information about the training program, contact:    

Todd T. Brown, MD, PhD
Director, T32 Clinical Research and Epidemiology
in Diabetes and Endocrinology Training Program
Email: tbrown27@jhmi.edu