Clinical Research and Epidemiology in Diabetes and Endocrinology
Wendy L. Bennett, MD, MPH
Associate Professor of Medicine
Research Director, General Internal Medicine
Todd T. Brown, MD, PhD
Professor of Medicine and Epidemiology
Division of Endocrinology, Diabetes, and Metabolism
Sheela N. Magge, MD, MSCE
Professor of Pediatrics
Director, Division of Pediatric Endocrinology and Diabetes
Diabetes mellitus has reached epidemic proportions in the US and abroad. Other endocrinologic diseases, like hypothyroidism and osteoporosis are also extraordinarily common. Patient- and population-oriented researchers with expertise in these conditions are urgently required.
With this need in mind, in 2002, we established a training program at Johns Hopkins devoted to clinical and epidemiologic research in diabetes and endocrinology and funded by the National Institute of Diabetes, Digestive, and Kidney Diseases (NIDDK). 20 years later, it remains the only one of its kind in the US. The training program accepts three pre-doctoral students and two post-doctoral fellows per year and leads them to the MHS or PhD in clinical epidemiology or clinical investigation. Thus far, we have successfully trained 50 young scholars (25 pre-docs and 25 post-docs) who have produced over 128 peer-reviewed scientific papers and who hold research positions across the country.
The goals of our training program are:
- To recruit a diverse group of top-notch young trainees in endocrinology (post-docs) and epidemiology (pre-docs) from a national pool of talent attracted to Johns Hopkins.
- To enroll them in rigorous, thesis-bearing Masters’ and PhD programs in Epidemiology and Clinical Investigation in the Johns Hopkins Bloomberg School of Public Health.
- To expose them to a strong team-oriented, multi-disciplinary clinical and epidemiologic research culture in the Welch Center—the premier educational home for clinical research training at Johns Hopkins.
- To guide each trainee to an experienced, NIH-funded mentor who will take responsibility for the successful completion of a significant thesis project.
The strengths of this program include:
- Strong existing diabetes and endocrine research collaborations between the Division of Endocrinology, Diabetes and Metabolism; Division of Pediatric Endocrinology; the Welch Center for Prevention, Epidemiology, and Clinical Research (Welch Center); the School of Public Health; and the School of Nursing
- Outstanding thesis-based degree programs in Epidemiology and Clinical Investigation at the School of Public Health
- Outstanding clinical expertise in diabetes and endocrine disorders
- Seasoned mentors experienced in grooming young scientists for academic careers, and
- High-caliber trainees wanting to pursue clinical and epidemiologic research careers related to diabetes and other endocrinology disorders.
Our pre-doctoral fellows are eligible for tuition support for their PhD program. Our post-doctoral trainees have the opportunity of pursuing a MHS or PhD in the Graduate Training Program in Clinical Investigation.
Areas Of Endocrine Research Training
Research Data Resources
National Health and Nutrition Examination Survey (NHANES)
Personal interview, physical exam, lab tests, nutritional assessment
National Health Interview Survey (NHIS)
Personal interview. ~ 40,000 household. Oversample blacks and Hispanics
Mortality Follow-ups for the NHANES and NHIS
NHANES III (baseline 1988 – 1994) has been linked to death through 2000. 9000-15,000 adults followed 8-12 years to mortality
Nation Hospital Discharge Survey (NHDS)
Hospital records, Computerized data sources from 500 hospitals with 300,000 discharges
Atherosclerotic Risk in Communities Study (ARIC)
Prospective cohort; 16,000 mid-aged adults from 4 U.S. communities
Multi-Ethnic Study of Atherosclerosis (MESA)
Prospective cohort from 6 sites with diverse and representative sample of ~ 7,000 men and women
|Jackson Heart Study (JHS)
Prosepective cohort of 5,200 African-American adults from Jackson, MS, USA
Studies risk factors for and progression of cardiovascular disease in African Americans
DPP Outcome Study (DPPOS)
Cohort after RCT; all DPP participants
Largest study of weight loss ever conducted; 5,000 participants with diabetes
Practice-Based Opportunities for Weight Reduction (POWER) Trial
Real world effectiveness trial designed to establish approaches to translate findings from major NIH lifestyle trials into clinical practice
Affiliated Research Centers And Departments
- Division of Endocrinology, Diabetes, and Metabolism
- Division of Pediatric Endocrinology and Diabetes
- Division of General Internal Medicine
- Welch Center for Prevention, Epidemiology and Clinical Research
- Bloomberg School of Public Health's Department of Epidemiology
- Johns Hopkins School of Nursing
- Johns Hopkins Center for Health Equity
- Center for Human Nutrition
- Johns Hopkins Center for Women's Health, Sex, and Gender Research
- Baltimore Metropolitan Diabetes Regional Partnership
For additional information about the training program, contact:
Todd T. Brown, MD, PhD
Director, T32 Clinical Research and Epidemiology
in Diabetes and Endocrinology Training Program