Forward Looking

This collection of resources, developed by the Global Task Force on Cholera Control (GTFCC) in collaboration with FIND, provides guidance for improving cholera surveillance through new rapid diagnostic tests (RDTs), DNA-based identification techniques, and molecular diagnostics. These documents are designed to support public health professionals, researchers, and manufacturers in developing and improving these methods. 

1. Target Product Profile for Cholera Rapid Diagnostic Tests: This profile focuses on creating tests that are affordable, easy to use, and adaptable for low-resource settings, aiming to improve cholera detection and monitoring in high-risk regions.
2. Introduction of DNA-Based Cholera Identification for Epidemiological Investigation: This technical note explores the benefits of DNA-based methods, such as Polymerase Chain Reaction (PCR) and Whole Genome Sequencing (WGS), for accurate tracking of cholera outbreaks. These techniques enable detailed insights into the genetic evolution of Vibrio cholerae, antimicrobial resistance, and the source of transmission, which are critical for targeted public health interventions.
3. Target Product Profile for Molecular Diagnostics in Cholera Surveillance: This profile highlights the specifications for molecular diagnostic tests using nucleic acid amplification, which are ideal for cholera surveillance in low-resource settings, with high sensitivity and specificity. These molecular tests are essential for rapid outbreak detection and continuous monitoring of cholera in endemic areas.