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William
R.
Bishai
,
MD

Professor

Departmental Affiliations

School of Medicine
Primary
Joint
Division
Global Disease Epidemiology and Control

Center & Institute Affiliations

Contact Info

1550 Orleans Street, CRB-II, Room 108
Baltimore
Maryland
21287
US        
410-614-8173

Research Interests

Molecular Microbiology and Immunology, Impact of Genome Information on Tuberculosis Research

Experiences & Accomplishments
Education
MD
Harvard Medical School
1989
PhD
Harvard Medical School
1989
MPhil
Cambridge University
1983
Overview

Tuberculosis pathogenesis Anti-TB drugs Animal models of TB and other respiratory pathogens

Select Publications
  • 1: Jain SK, Hernandez-Abanto SM, Cheng QJ, Singh P, Ly LH, Klinkenberg LG, Morrison NE, Converse PJ, Nuermberger E, Grosset J, McMurray DN, Karakousis PC, Lamichhane G, Bishai WR. Accelerated detection of Mycobacterium tuberculosis genes essential for bacterial survival in guinea pigs, compared with mice. J Infect Dis. 2007 Jun 1;195(11):1634-42. Epub 2007 Apr 23. PMID: 17471433 [PubMed - indexed for MEDLINE]

  • 2: Lun S, Bishai WR. Characterization of a novel cell wall-anchored protein with carboxylesterase activity required for virulence in Mycobacterium tuberculosis. J Biol Chem. 2007 Jun 22;282(25):18348-56. Epub 2007 Apr 11. PMID: 17428787 [PubMed - in process]

  • 3: Williams EP, Lee JH, Bishai WR, Colantuoni C, Karakousis PC. Mycobacterium tuberculosis SigF regulates genes encoding cell wall-associated proteins and directly regulates the transcriptional regulatory gene phoY1. J Bacteriol. 2007 Jun;189(11):4234-42. Epub 2007 Mar 23. PMID: 17384187 [PubMed - in process]

  • 4: Anzueto A, Bishai WR, Pottumarthy S. Role of oral extended-spectrum cephems in the treatment of acute exacerbation of chronic bronchitis. Diagn Microbiol Infect Dis. 2007 Mar;57(3 Suppl):S31-8. PMID: 17349461 [PubMed - in process]

  • 5: Lamichhane G, Bishai W. Defining the 'survivasome' of Mycobacterium tuberculosis. Nat Med. 2007 Mar;13(3):280-2. No abstract available. PMID: 17342137 [PubMed - indexed for MEDLINE]

Projects
Gene Regulation and Virulence in TB and MAC
Mycobacterium tuberculosis Survival Regulatory Genes
Screen for Synthetic Lethality in Mycobacterium Tuberculosis
New Animal Models for Tuberculosis
Biomarkers and Signaling in Tuberculosis
Innovative approach to basic science Masters and PhD training with a research focus on human infectious diseases in Durban, South Africa