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Associate Professor
Andrew Jaffe

Departmental Affiliations

School of Medicine

Contact Info

855 N. Wolfe Street, Suite 300

Research Interests

Psychiatric Genomics; Computational Biology; Bioinformatics; Human Genetics
Experiences & Accomplishments
Johns Hopkins Bloomberg School of Public Health
Johns Hopkins Bloomberg School of Public Health
I work largely at the intersection of genomics, biostatistics, and computational biology, leveraging large datasets to better understand how genomic signatures associate with human brain development and subsequent dysregulation in mental illness. My research consists of several broad, and often overlapping, domains: 1) developing statistical methodology and corresponding software tools for the spatial analysis of epigenomic and transcriptomic data across the genome, 2) developing and applying computational approaches in genomic data to identify new biological insights in development and aging, and 3) identifying molecular signatures related to causes and consequences of mental disorders in human postmortem brain samples.
Honors & Awards
2013: The James V. Neel Young Investigator Award for Best Platform Presentation, 22nd Annual Conference of the International Genetic Epidemiology Society)
2012: Young Investigator Award, Statistics in Epidemiology Section, American StatisticalAssociation
2011: The Louis I. and Thomas D. Dublin Award for the Advancement of Epidemiology and Biostatistics (Department of Biostatistics and Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health)
Select Publications
My work largely focuses on psychiatric genomics, transcriptomics, and epigenomics in the human brain
  • Jaffe AE, Gao Y, Deep-Soboslay A, Tao R, Hyde TM, Weinberger DR, Kleinman JE Mapping DNA methylation across development, genotype, and schizophrenia in the human frontal cortex. Nature Neuroscience. 2016 Jan;19(1):40-7. PMID: 26619358
  • Jaffe AE, Shin J, Collado-Torres L, Leek JT, Tao R, Li C, Gao Y, Jian Y, Maher BJ, Hyde TM, Kleinman JE, Weinberger DR. Developmental regulation of human cortex transcription at base resolution. Nat Neurosci. 2015 Jan;18(1):154-61. PMID: 25501035. 
  • Ivanov NA, Tao R, Chenoweth JG, Brandtjen A, Mighdoll MI, Genova JD, McKay RD, Jia Y, Weinberger DR, Kleinman JE, Hyde TM, Jaffe AE. Strong Components of Epigenetic Memory in Cultured Human Fibroblasts Related to Site of Origin and Donor Age. PLoS Genet. 2016 Feb 25;12(2):e1005819. PMID: 26913521
  • Jaffe AE, Irizarry RA. Accounting for cellular heterogeneity is critical in epigenome-wide association studies. Genome Biol. 2014 Feb 4;15(2):R31 (Epub). PMID: 24495553
  • Jaffe AE, Murakami P, Lee H, Fallin MD, Leek JT, Feinberg AP, Irizarry RA. Bump hunting to identify differentially methylated regions in epigenetic epidemiology studies. Int. J. Epidemiol. (2012)  41 (1):200-209. PMID: 22422453