Research
Our faculty engage in research, evidence synthesis, and methodology development, design, and coordination across a diverse array of health issues. Our faculty are experts in the conduct and optimization of clinical trials, conducting research activities and providing services that advance excellence in evidence-based health care. We serve as a coordinating center for highly complex, multi-site, and international trials, collaborating with peers to design, conduct, and synthesize high-quality studies across diverse disciplines. We invite peers and students to connect, collaborate, or consult with our faculty. Explore their individual areas of interest and ongoing projects.
Our Work
Clinical trials
Our Center both conducts and coordinates clinical trials, observational studies, cohort studies, and more. Across diverse health care topics, our researchers and students investigate the safety and effectiveness of interventions and the variables that affect health. To connect with an expert in your area of interest or collaborate on a trial, explore our faculty research.
Trial coordination
The Center serves as a coordinating center for complex, multi-site, and international trials, collaborating with peers around the world to design, conduct, and synthesize high-quality studies across an array of health topics.
Evidence synthesis
Our Center conducts systematic reviews and meta-analyses of data and findings from published literature to synthesize findings and inform clinical practice.
Methodology
Our faculty offer expertise in coordinating, applying, and developing conventional and innovative methodologies for conducting and reporting clinical trials and systematic reviews. We design, deploy, and teach the full spectrum of investigative methodologies related to clinical trials, evidence syntheses, and related reporting. Through the Trial Advisor Program, our expert faculty consult with peers on study design, trial operations, and analysis plans.
Graduate training
The Center offers graduate-level training within the Department of Epidemiology. Students can enroll in introductory and advanced courses in clinical trials, data management, and trial analysis techniques across a range of health care disciplines as well as courses in epidemiologic methods, systematic reviews, meta-analysis, and network meta-analysis. Learn more about the Clinical Trials and Evidence Synthesis track and the Clinical Trials Certificate Program.
Our Research
Design and conduct of clinical trials
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Adaptive Trial Designs (Elizabeth Sugar)
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Bias in conduct of systematic reviews and meta-analysis (Ann Margret Ervin)
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Causal inference and outcome harmonization across multiple (interventional and observational) cohorts (Stephan Ehrhardt)
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Ethics of trials (Curtis Meinert, Ann Margret Ervin)
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Graphical Techniques for Monitoring and Reporting Clinical Trials (Elizabeth Sugar)
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Innovative methods for (interventional and observational) data coordinating centers (Stephan Ehrhardt)
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Registration and reporting guidelines (Curtis Meinert, Ann Margret Ervin)
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Stakeholder engagement in research (Ann Margret Ervin)
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State and nature of clinical trials (Curtis Meinert)
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Streamlining Clinical Trials (Janet Holbrook, David Shade, Elizabeth Sugar)
Infectious diseases
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Antibiotic-associated diarrhea (Stephan Ehrhardt)
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HIV/AIDS (, Elizabeth Sugar)
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HPV (Elizabeth Sugar)
Lung and cardiovascular health
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Asthma (Janet Holbrook, David Shade, Elizabeth Sugar)
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COPD (Janet Holbrook, Elizabeth Sugar)
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Stroke (Elizabeth Sugar)
Maternal and child health
- Mother to Child Transmission of Hepatitis B (Stephan Ehrhardt)
Mental health
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Anxiety (Stephan Ehrhardt)
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Depression (Stephan Ehrhardt)
Neurological health
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Vestibular disorders (Ann Margret Ervin)
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Dementia (Stephan Ehrhardt, David Shade, Ann Margret Ervin)
Oncology
- Oncology (Elizabeth Sugar)
Vision health
- Eyes and vision (Janet Holbrook, Elizabeth Sugar, Ann Margret Ervin, Douglas Jabs, Sheriza Baksh)
- Uveitis (Janet Holbrook, Elizabeth Sugar, Douglas Jabs)